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首页> 外文期刊>Chemistry: A European journal >Precise Synthesis of Poly(macromonomer)s Containing Sugars by Repetitive ROMP and Their Attachments to PoIy(ethyIene glycol):Synthesis,TEM Analysis and Their Properties as Amphiphilic Block Fragments
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Precise Synthesis of Poly(macromonomer)s Containing Sugars by Repetitive ROMP and Their Attachments to PoIy(ethyIene glycol):Synthesis,TEM Analysis and Their Properties as Amphiphilic Block Fragments

机译：通过重复的嬉戏的含糖和它们对Poiy（乙基乙二醇）的附件精确合成含糖：合成，TEM分析及其属性作为Amphiphic块片段

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摘要

Various poly(macromono-mer)s(PMMs)have been prepared by a repeating ring opening metathesis polymerization(ROMP)technique using the well-defined molybdenum initiators of the type,[Mo(CHCMe2Ph)-(NAr)(OR)2] with OR = OCMe3,OCMeC(CF3)2;Ar = 2,6-iPr2C6H3,2,6-Me2C6H3.The synthetic strategy is based on the polymerization of norbor-nene and its derivatives affording di-and triblock side chains bearing sugars(mannose,galactose,glucose etc.),linked via O-(ester),and glycosidase resistant C-(isoxazoline)glycosides.The efficient placement of norbornene units on the side chain termini and their conversion into PMMs,facilitated by the Mo alkylidenes,proceeded in a living manner with the quantitative initiation.The methodology was applied to prepare poly(macromonomer)-graft-PEG [PEG:poly(ethylene glycol)],by the attachment of a pseudo phenol terminus on the PMM main chain to PEG-Ms2 [MsO(CH2CH2O)_nMs,Ms = MeSO2] using a "grafting to" approach.Removal of the acetal protecting groups from the sugar coating of a vari- ety of supramolecular structures including PMMs,linear amphiphilic block copolymers(ABC)and a PMM-graft-PEG by using trifluroacetic acid/ water(9:1),and suspension in water,prompted the spontaneous formation of spherical architectures by self-assembly of the amphiphilic PMMs as observed by transmission electron microscopy(TEM).The ability to uptake the hydrophobic dye(Nile Red)into the micellar cores of a variety of amphiphilic polymeric fragments is a significant step towards the production of sugar-coated nanospheres for cell-targeting biomimetic applications.
机译：通过使用类型的明确定义的钼引发剂，通过重复的环开口复分解聚合（ROMP）技术来制备各种聚（MACROMONO-MER）S（PMMS），[MO（CHCME2PH） - （NAR）（或）2]与OR = OCME3，OCMEC（CF3）2; AR = 2,6-IPR2C6H3,2,6-ME2C6H3。合成策略基于NORBOR-NENE的聚合及其衍生物，其提供含糖的DI-and TRIBLOCK侧链（甘露糖，半乳糖，葡萄糖等。），通过O-（酯）和糖苷酶抗性C-（异恶唑啉）糖苷连接。降冰片烯单元在侧链末端的有效位置及其转化为PMM，由Mo烷基促进，以定量引发以生命的方式进行。通过将PMM主链上的伪酚末端连接到PEG - MS2 [MSO（CH2CH2O）_NMS，MS = MESO2]使用“移植到”方法。来自糖CO的缩醛保护基团通过使用三氟乙酸/水（9：1）和悬浮在水中，在包括PMM，线性两亲嵌段共聚物（ABC）和PMM-移植物和PMM-移植物和PMM-移植物的变常数的含量。促进了球形架构的自发地形成通过透射电子显微镜（TEM）观察到的两亲PMM的自组装。将疏水染料（尼罗红）吸入各种两亲性聚合物片段的胶束芯的能力是朝向生产糖的重要步骤 - 用于细胞靶向仿生应用的涂覆纳米球。

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