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首页> 外文期刊>Chemistry: A European journal >Crosslinked Network with Rotatable Binding Sites Based on Monocarboxylated α-Cyclodextrin [2]Rotaxane Capable of Angiotensin III Recognition
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Crosslinked Network with Rotatable Binding Sites Based on Monocarboxylated α-Cyclodextrin [2]Rotaxane Capable of Angiotensin III Recognition

机译：具有基于单羧基化α-环糊精的可旋转结合位点的交联网络[2]亚甲烷能够血管紧张素III识别

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摘要

Synthetic receptors selective for target peptides or proteins have received attention because of their potential applications in the separation of biomolecules and biomedical diagnostics. Herein, a [2]rotaxane-based functional monomer containing monocarboxylated α-cyclodextrin (α-CD) was synthesized, and its crosslinked polymers were evaluated to determine their binding ability to a model peptide, angiotensin III (Arg-Val-Tyr-Ile-His-Pro-Phe), containing an arginine (Arg) residue. The binding ability of the resulting polymers toward angiotensin III, angiotensin IV (Val-Tyr-Ile-His- Pro-Phe), and FMRF-amide (Phe-Met-Arg-Phe) was examined by the batch-binding assay and compared with that of control polymers, in which maleic acid-introduced α-CD was chemically crosslinked. The results suggest that the [2]rotaxane- based functional monomer in the crosslinked polymer contributes to the high affinity toward angiotensin III. The a- CD motion and rotation within the [2]rotaxane-based crosslinked polymer may be applicable for designing molecular recognition materials.
机译：由于它们在分离生物分子和生物医学诊断中的潜在应用，因此对靶肽或蛋白选择的合成受体受到关注。在此，合成了含有一元羧酸α-环糊精（α-CD）的[2]旋霉素的官能单体，并评价其交联聚合物以确定其对模型肽，血管紧张素III的结合能力（ARG-VAL-TYR-ILE -HIS-PRO-PHE），含有精氨酸（ARG）残留物。通过间歇结合测定检查所得聚合物朝向血管紧张素III，血管紧张素IV（VAL-TYR-IL-HIS-PHE）和FMRF - 酰胺（PHE-MET-ARG-PHE）的结合能力并进行比较具有对照聚合物的，其中马来酸引入的α-CD化学交联。结果表明，交联聚合物中的[2]替代的基官能单体有助于对血管紧张素III的高亲和力。 [2]旋霉素的交联聚合物内的A-CD运动和旋转可适用于设计分子识别材料。

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