Vitamin B_(12) Catalysis: Probing the Structure/Efficacy Relationship

Maksymilian Karczewski; Micha? Ociepa; Katarzyna Pluta; Keith ó Proinsias

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Vitamin B_(12) Catalysis: Probing the Structure/Efficacy Relationship

机译：维生素B_（12）催化：探测结构/疗效关系

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Vitamin B_(12) is a cofactor for many enzymes, but it also functions as a catalyst in C-C bond-forming reactions. Herein, the impact of corrin structural modifications on their catalytic efficacy was examined. Derivatives with various substituents at c-, d-, and meso-positions were synthesised by using traditional and new microwave methodologies, and then tested in the model reaction of 1,1-diphenylethylene with ethyl diazoacetate. To complement the experimental data, cyclic voltammetry and DFT calculations were performed. Mainly alterations at the c- or d-positions influence both the reaction yield and selectivity.

机译：维生素B_（12）是许多酶的辅因子，但它也用作C-C键形成反应中的催化剂。在此，研究了检查科学结构修饰对其催化功效的影响。通过使用传统和新的微波方法合成C-，D-和中间位置的各种取代基的衍生物，然后在1,1-二苯基乙烯的模型反应中用乙基二酰乙酸酯进行测试。为了补充实验数据，进行循环伏安法和DFT计算。主要在C-或D-POSITY的改变会影响反应产率和选择性。

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来源
《Chemistry: A European journal》 |2017年第29期|共7页
作者
Maksymilian Karczewski; Micha? Ociepa; Katarzyna Pluta; Keith ó Proinsias;
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作者单位

M. Karczewski M. Ociepa K. Pluta Dr. K. j Proinsias Prof. D. Gryko Institute of Organic Chemistry Polish Academy of Sciences Kasprzaka 44/52 01-224 Warsaw (Poland);

M. Karczewski M. Ociepa K. Pluta Dr. K. j Proinsias Prof. D. Gryko Institute of Organic Chemistry Polish Academy of Sciences Kasprzaka 44/52 01-224 Warsaw (Poland);

M. Karczewski M. Ociepa K. Pluta Dr. K. j Proinsias Prof. D. Gryko Institute of Organic Chemistry Polish Academy of Sciences Kasprzaka 44/52 01-224 Warsaw (Poland);

M. Karczewski M. Ociepa K. Pluta Dr. K. j Proinsias Prof. D. Gryko Institute of Organic Chemistry Polish Academy of Sciences Kasprzaka 44/52 01-224 Warsaw (Poland);

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原文格式 PDF
正文语种 eng
中图分类应用化学;
关键词
diazo compounds; homogeneous catalysis; natural products; structure–activity relationships; substituent effects;

机译：重氮化合物;均匀催化;天然产品;结构 - 活性关系;取代效应;

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专利

1. Vitamin B_(12) Catalysis: Probing the Structure/Efficacy Relationship [J] . Maksymilian Karczewski, Micha? Ociepa, Katarzyna Pluta, Chemistry: A European journal . 2017,第29期

机译：维生素B_（12）催化：探测结构/疗效关系
2. Short communication: Relationships among plasma and milk vitamin B_(12), plasma free fatty acids, and blood β-hydroxybutyrate concentrations in early lactation dairy cows [J] . M. Duplessis, R.I. Cue, D.E. Santschi, Journal of dairy science . 2018,第9期

机译：简短交流：泌乳早期奶牛血浆和牛奶中的维生素B_（12），血浆游离脂肪酸与血液中β-羟基丁酸酯浓度之间的关系
3. A new paradigm for electrostatic catalysis of radical reactions in vitamin B_(12) enzymes [J] . Pankaz K. Sharma, Zhen T. Chu, Mats H. M. Olsson, Proceedings of the National Academy of Sciences of the United States of America . 2007,第23期

机译：维生素B_（12）酶中自由基反应的静电催化新范式
4. Quantum Mechanical Approach to Understanding of Vitamin B_(12) Dependent Enzyme Catalysis [C] . S. C.Ke CCAST-WL Workshop Series: vol 121; Cross-Straits Symposium on Biology-Inspired Theoretical Problems and China Center of Advanced Science and Technology(CCAST) (World Laboratory) Workshop; 20000515-19; Beijing(CN) . 2000

机译：理解维生素B_（12）依赖酶催化的量子力学方法
5. The relationships between food insecurity and iron, folate and vitamin B(12) status in the elderly [D] . Hinds, Hesma Eliza 2006

机译：粮食不安全与老年人铁，叶酸和维生素B（12）状况之间的关系
6. Structure-function relationships in the cysteine proteinases actinidin papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by two-hydronic-state reactivity probe kinetics and kinetics of catalysis. [O] . C M Topham, E Salih, C Frazao, 1991

机译：半胱氨酸蛋白酶actinidin木瓜蛋白酶和木瓜蛋白酶欧米茄中的结构-功能关系。木瓜蛋白酶欧米茄的三维结构由基于知识的模型推导和由两个水力状态反应探针动力学和催化动力学确定的活性中心特性。
7. Use of Parallel Synthesis To Probe Structure-Activity Relationships among 12-Helical b-Peptides: Evidence of a Lower Limit on Antimicrobial Activity [O] . -1

机译：使用平行合成在12螺旋B-肽之间的探针结构 - 活性关系：抗菌活性下限的证据

Vitamin B_(12) Catalysis: Probing the Structure/Efficacy Relationship

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