Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F: Rare Tropolone Alkaloids from Actinomadura sp. 5-2

Huijuan Guo; René Benndorf; Daniel Leichnitz; Jonathan L. Klassen; John Vollmers; Helmar G?rls; Matthias Steinacker; Christiane Weigel; Hans-Martin Dahse; Anne-Kristin Kaster; Z. Wilhelm de Beer; Michael Poulsen; Christine Beemelmanns

首页> 外文期刊>Chemistry: A European journal >Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F: Rare Tropolone Alkaloids from Actinomadura sp. 5-2

【24h】

Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F: Rare Tropolone Alkaloids from Actinomadura sp. 5-2

机译：鲁伯罗酮A-F的分离，生物合成和化学修饰：抗菌菌稀土覆盖物的稀土生物碱。 5-2

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The discovery of six new, highly substituted tropolone alkaloids, rubterolones A-F, from Actinomadura sp. 5-2, isolated from the gut of the fungus-growing termite Macrotermes natalensis is reported. Rubterolones were identified by using fungus-bacteria challenge assays and a HRMSbased dereplication strategy, and characterised by NMR and HRMS analyses and by X-ray crystallography. Feeding experiments and subsequent chemical derivatisation led to a first library of rubterolone derivatives (A-L). Genome sequencing and comparative analyses revealed their putative biosynthetic pathway, which was supported by feeding experiments. This study highlights how gut microbes can present a prolific source of secondary metabolites.

机译：从Actinomadura SP发现六种新的高度取代的Troblouralals，Rubterolones A-F的发现。据报道，从肠道的肠道中分离出来，据报道了肠道的肠道。通过使用真菌 - 细菌挑战测定和HRMS基于统计策略来鉴定鲁布酮，并通过NMR和HRMS分析和通过X射线晶体表征。进料实验和随后的化学衍生化导致了葡萄酒衍生物（A-L）的第一文库。基因组测序和比较分析显示了其推定的生物合成途径，其通过喂养实验支持。这项研究突出了肠道微生物可以出现次要代谢物的多产来源。

著录项

来源
《Chemistry: A European journal》 |2017年第39期|共8页
作者
Huijuan Guo; René Benndorf; Daniel Leichnitz; Jonathan L. Klassen; John Vollmers; Helmar G?rls; Matthias Steinacker; Christiane Weigel; Hans-Martin Dahse; Anne-Kristin Kaster; Z. Wilhelm de Beer; Michael Poulsen; Christine Beemelmanns;
展开▼
作者单位

Leibniz Institute for Natural Product Research and Infection Biology Hans Kn?ll Institute Beutenbergstra?e 11a 07745 Jena (Germany);

Leibniz Institute for Natural Product Research and Infection Biology Hans Kn?ll Institute Beutenbergstra?e 11a 07745 Jena (Germany);

Leibniz Institute for Natural Product Research and Infection Biology Hans Kn?ll Institute Beutenbergstra?e 11a 07745 Jena (Germany);

Molecular and Cell Biology University of Connecticut 91 North Eagleville Road Storrs CT 06269-3125 (USA);

Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures Inhoffenstra?e 7B 38124 Braunschweig (Germany);

Institute of Inorganic and Analytical Chemistry Friedrich-Schiller-University Jena Lessingstra?e 8 07743 Jena (Germany);

Leibniz Institute for Natural Product Research and Infection Biology Hans Kn?ll Institute Beutenbergstra?e 11a 07745 Jena (Germany);

Leibniz Institute for Natural Product Research and Infection Biology Hans Kn?ll Institute Beutenbergstra?e 11a 07745 Jena (Germany);

Leibniz Institute for Natural Product Research and Infection Biology Hans Kn?ll Institute Beutenbergstra?e 11a 07745 Jena (Germany);

Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures Inhoffenstra?e 7B 38124 Braunschweig (Germany);

Department of Microbiology and Plant Pathology Forestry and Agriculture Biotechnology Institute University of Pretoria Pretoria (South Africa);

Centre for Social Evolution University of Copenhagen 2100 Copenhagen East (Denmark);

Leibniz Institute for Natural Product Research and Infection Biology Hans Kn?ll Institute Beutenbergstra?e 11a 07745 Jena (Germany);

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类应用化学;
关键词
biosynthesis; chemical probes; drug discovery; natural products; polyketides;

机译：生物合成;化学探针;药物发现;天然产品;聚酮基;

相似文献

外文文献
中文文献
专利

1. Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F: Rare Tropolone Alkaloids from Actinomadura sp. 5-2 [J] . Huijuan Guo, René Benndorf, Daniel Leichnitz, Chemistry: A European journal . 2017,第39期

机译：鲁伯罗酮A-F的分离，生物合成和化学修饰：抗菌菌稀土覆盖物的稀土生物碱。 5-2
2. Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces [J] . Yan Yijun, Ma Ya-Tuan, Yang Jing, Organic letters . 2016,第6期

机译：内酯链霉菌阳离子托酚酮生物碱Rubrolone B生物合成中的托酚酮环构建
3. Isolation Of Notoamide E, A Key Precursor In The Biosynthesis Of Prenylated Indole Alkaloids In A Marine-derived Fungus, Aspergillus Sp. [J] . Sachiko Tsukamoto, Hikaru Kato, Thomas J. Greshock, Journal of the American Chemical Society . 2009,第11期

机译：海洋生物真菌曲霉菌中烯丙基化吲哚生物碱的生物合成关键前体诺酰胺E的分离
4. Study of biosorption of rare earth metals (La, Nd, Eu, Gd) by Sargassum sp. biomass in batch systems: physicochemical evaluation of kinetics and adsorption models [C] . R. C. Oliveira, O. Garcia Jr. International Biohydrometallurgy Symposium . 2009

机译：Sargassum SP的稀土金属（La，Nd，Eu，Gd）生物吸附研究。 BioMass分批系统：物理化学评估动力学和吸附模型
5. Characterization of G10H promoter and isolation of WRKY transcription factors involved in Catharanthus terpenoid indole alkaloid biosynthesis pathway [D] . Suttpanta, Nitima. 2012

机译：Cathranthus Terpenoid Indole生物合成途径鉴定G10H启动子的表征及腕式转录因子的分离
6. Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids [O] . Yijun Yan, Jing Yang, Zhiyin Yu, -1

机译：异丁烷酮托酚酮生物碱生物合成中的非酶吡啶环形成
7. Isolation of Notoamide E, a Key Precursor in the Biosynthesis of Prenylated Indole Alkaloids in a Marine-Derived Fungus, Aspergillus sp. [O] . Sachiko Tsukamoto, Hikaru Kato, Thomas J. Greshock, 2009

机译：在海洋衍生的真菌中戊酰胺吲哚生物碱生物合成中的关键前体的分离，亚霉菌，Aspergillus sp。
8. Isolation, Biosynthesis and Biological Activity of Alkaloids of Tylophora Asthmatica, a Versatile Medicinal Plant [R] . Mulchandani, N. B. 1987

机译：多功能药用植物Tylophora asthmatica生物碱的分离，生物合成和生物活性

Isolation, Biosynthesis and Chemical Modifications of Rubterolones A-F: Rare Tropolone Alkaloids from Actinomadura sp. 5-2

摘要

著录项

相似文献

相关主题

期刊订阅