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首页> 外文期刊>Chemistry: A European journal >Molecularly Imprinted Polymer Chemosensor for Selective Determination of an N-Nitroso-l-proline Food Toxin
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Molecularly Imprinted Polymer Chemosensor for Selective Determination of an N-Nitroso-l-proline Food Toxin

机译：用于选择性测定N-Nitroso-L-脯氨酸食物毒素的分子印迹聚合物化学传感器

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摘要

A molecularly imprinted polymer (MIP)-based chemosensor for the selective determination of a chosen toxin, N-nitroso-l-proline (Pro-NO), was devised and fabricated. By means of DFT, the structure of the pre-polymerization (functional monomer)-template complex was modeled. This complex was then potentiodynamically electropolymerized in the presence of cross-linking monomer to form a MIP-Pro- NO thin film. Next, the Pro-NO template was extracted from MIP-Pro-NO with 0.1m NaOH. Piezoelectric microgravimetry (PM) on an electrochemical quartz crystal microbalance and electrochemical (differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS)) techniques were used to transduce binding of Pro-NO to molecular cavities of the MIP-Pro-NO. With DPV and EIS chemosensing, the limits of detection (LODs) were about 80.9 and 36.9 nM Pro- NO, respectively; and the selectivity coefficients for urea, glucose, creatinine, and adrenalin interferences were 6.6, 13.2, 2.1, and 2.0, respectively, with DPV as well as 2.3, 2.0, 3.3, and 2.5, respectively, with EIS. With PM under flow injection analysis conditions, the LOD was 10 mm Pro-NO. The MIP-Pro-NO chemosensor detectability and selectivity with respect to interferences were sufficiently high to determine Pro-NO in protein-providing food products.
机译：为选择性测定选择的毒素N-Nitroso-L-脯氨酸（Pro-No）的分子印迹聚合物（MIP）的化学传感器被设计和制造。通过DFT，模拟预聚合预聚合（功能单体）的结构。然后在交联单体存在下使该络合物电位地电极聚集以形成MIP-Pro-NO薄膜。接下来，通过0.1M NaOH从MIP-Pro-No中提取Pro-No模板。在电化学石英晶体微稳定和电化学（差分脉冲伏安法（DPV）和电化学阻抗谱（EIS）上的压电微血液测定法（PM）用于将Pro-NO的结合转导到MIP-PRO-NO的分子腔的结合。具有DPV和EIS化学溶解，检测限（LOD）分别为80.9和36.9 nm-no。并且尿素，葡萄糖，肌酐和肾上腺素干扰的选择性系数分别为6.6,13.2,2.1和2.0，分别具有EIS的DPV和2.3,2.0,3.3和2.5分别。随着PM在流动注射分析条件下，LOD为10毫米PRO-NO。 MIP-Pro-No Chemosensor可检测性和相对于干扰的选择性足够高，以确定蛋白质提供食品的Pro-No。

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