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首页> 外文期刊>Chemistry: A European journal >Rational Development of Near-Infrared Fluorophores with Large Stokes Shifts, Bright One-Photon, and Two-Photon Emissions for Bioimaging and Biosensing Applications
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Rational Development of Near-Infrared Fluorophores with Large Stokes Shifts, Bright One-Photon, and Two-Photon Emissions for Bioimaging and Biosensing Applications

机译：具有大型斯托克斯的近红外荧光团的合理发育，用于生物体和生物传感应用的偏振，明亮的单光子和双光子排放

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摘要

Fluorophores with near-infrared emissions play a crucial role in numerous bioimaging and biosensing applications, owing to their deep penetration depths, low autofluorescence, and minimal tissue damages. Herein, the rational development of a new class of near-infrared fluorophores with bright one-photon and two-photon emissions at ≈740 nm, large Stokes shifts (≈80 nm), significant twophoton action absorption cross-section (≈185 GM at 820 nm), excellent water solubility, outstanding photostability, and low toxicity is reported. Their biological applications in mitochondrial labelling, deep tissue imaging, and H_2S detection in live cells and mice are also demonstrated. In addition, a rational design strategy for enlarging the Stokes shifts and enhancing two-photon emissions of these fluorophores is presented. These fluorophores will serve as a useful platform for developing novel imaging and sensing agents, and the design methodologies will inspire the molecular engineering of abundant high-performance near-infrared fluorophores.
机译：具有近红外排放的荧光团在许多生物分析和生物传感应用中起着至关重要的作用，由于它们的深度渗透深度，低自发荧光和最小的组织损坏。在此，新类近红外荧光团的合理发育，具有明亮的单光子和双光子排放，大斯托克斯班次（≈80nm），重要的纺酚动作吸收横截面（≈185克报道了820nm），优异的水溶性，出色的光稳定性和低毒性。还证明了它们在线粒体标记，深层组织成像和活细胞和小鼠中检测的生物学应用。此外，介绍了扩大斯托克斯的理性设计策略，提出了这些荧光团的两光子发射的转变和增强。这些荧光团将作为开发新型成像和传感剂的有用平台，并且设计方法将激发丰富的高性能近红外荧光团的分子工程。

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  • 来源
    《Chemistry: A European journal》 |2017年第36期|共5页
  • 作者

    Liyi Zhou; Qianqian Wang; Yi Tan; Matthew J. Lang; Hongyan Sun; Xiaogang Liu;

  • 作者单位

    College of Food Science and Technology Central South University of Forestry and Technology Changsha Hunan 410004 (P. R. China);

    State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University Changsha Hunan 410082 (P. R. China);

    Department of Biology and Chemistry City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong (P. R. China);

    Singapore-MIT Alliance for Research and Technology (SMART) 1 CREATE Way Singapore 138602 (Singapore);

    Department of Biology and Chemistry City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong (P. R. China);

    Singapore-MIT Alliance for Research and Technology (SMART) 1 CREATE Way Singapore 138602 (Singapore);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    fluorescence; fluorescent probes; hydrogen sulphide; near-infrared; two-photon;

    机译：荧光;荧光探针;硫化氢;近红外;双光子;

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