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Enantioselective Rauhut–Currier-Type 1,6-Conjugate Addition of Methyl Vinyl Ketone to para-Quinone Methides

机译:映选择性的Rauhut-Currier-型1,6-缀合物加入甲基乙烯基酮至对醌甲基化物

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摘要

An unprecedented Rauhut–Currier-type 1,6-conjugate addition has been developed. With chiral cyclohexane- based phosphine-amide catalyst 3h, the 1,6-conjugate reaction has been achieved to produce chiral diarylmethine compounds in excellent yields (91–99%) and enantioselectivities (92–98% ee).
机译:已经开发出一个前所未有的Rauhut-type 1,6-共轭添加。 采用手性环己烷基磷酸氨催化剂3H,已经实现了1,6-缀合物反应,以产生优异产率(91-99%)和对映射性(92-98%EE)的手性二芳基化合物。

著录项

  • 来源
    《Chemistry: A European journal》 |2017年第27期|共5页
  • 作者单位

    Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry &

    Molecular Engineering East China University of Science and Technology Shanghai 200237 (P. R. China);

    Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry &

    Molecular Engineering East China University of Science and Technology Shanghai 200237 (P. R. China);

    Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry &

    Molecular Engineering East China University of Science and Technology Shanghai 200237 (P. R. China);

    Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry &

    Molecular Engineering East China University of Science and Technology Shanghai 200237 (P. R. China);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    asymmetric catalysis; chiral phosphine; conjugation; quinone methide; rauhut-currier;

    机译:不对称催化;手性膦;共轭;醌甲基酸;Rauhut-Clyier;

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