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首页> 外文期刊>Chemistry: A European journal >Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer's Disease
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Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer's Disease

机译：结构和机械洞察化学工具的发展，以控制阿尔茨海默病中的个体和相关病理特征

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摘要

To elucidate the involvement of individual and inter-related pathological factors [i.e., amyloid-β (Aβ), metals, and oxidative stress] in the pathogenesis of Alzheimer's disease (AD), chemical tools have been developed. Characteristics required for such tool construction, however, have not been clearly identified; thus, the optimization of available tools or new design has been limited. Here, key structural properties and mechanisms that can determine tools' regulatory reactivities with multiple pathogenic features found in AD are reported. A series of small molecules was built up through rational structural selection and variations onto the framework of a tool useful for in vitro and in vivo metal-Aβ investigation. Variations include: (i) location and number of an Aβ interacting moiety; (ii) metal binding site; and (iii) denticity and structural flexibility. Detailed biochemical, biophysical, and computational studies were able to provide a foundation of how to originate molecular formulas to devise chemical tools capable of controlling the reactivities of various pathological components through distinct mechanisms. Overall, this multidisciplinary investigation illustrates a structure- mechanism-based strategy of tool invention for such a complicated brain disease.
机译：为了阐明个体和相关的病理因素的累积[即淀粉样蛋白-β（Aβ），金属和氧化应激]在阿尔茨海默病（AD）的发病机制中，已经开发出化学工具。然而，这种工具结构所需的特性尚未明确识别;因此，可用工具或新设计的优化受到限制。在此，据报道，可以确定具有在广告中发现的多种致病特征的工具的调节重组的关键结构性质和机制。通过合理的结构选择和对体外和体内金属-Aβ调查的工具框架的变化来建立一系列小分子。变型包括：（i）Aβ相互作用部分的位置和数量; （ii）金属结合位点; （iii）牙本质和结构性灵活性。详细的生化，生物物理和计算研究能够为如何通过独特机制来提供如何源自分子公式的分子公式的基础，以通过不同的机制来控制各种病理成分的反应性的化学工具。总的来说，这种多学科调查显示了用于这种复杂的脑疾病的刀具发明的基于结构机制的策略。

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