Synchronized Chiral Induction between [5]Helicene-Spermine Ligand and B-Z DNA Transition

Kensuke Kawara; Genichiro Tsuji; Yosuke Taniguchi; Shigeki Sasaki

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Synchronized Chiral Induction between [5]Helicene-Spermine Ligand and B-Z DNA Transition

机译：[5]甲丙烯 - 精牙配体和B-Z DNA过渡之间的同步手性诱导

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摘要

The 2,13-dimethoxy[5]helicene-spermine ligand 8b possesses an axial chirality. The racemic 8b was bound to B-DNA by the accompanying induction of its (P)-chirality together with the B-to-Z helicity change of the duplex DNA, [(dC-dG)_3]_2. The (P)-chirality of the bound 8b, in turn, transitioned to the (M)-chirality according to the Zhelicity of the DNA. These results illustrate the chirality synchronization between the DNA and the ligand.

机译：2,13-二甲氧基[5]甲肾上腺素配体8b具有轴向手性。通过伴随其（P） - 高潮的诱导与双相DNA的B-TO-Z肝脏变化一起与B-DNA结合到B-DNA，[（DC-DG）_3] _2。反过来，结合8B的（P）的高呼吸转变为根据DNA的中部的（M）的高度转变为（M）。这些结果说明了DNA和配体之间的手性同步。

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来源
《Chemistry: A European journal》 |2017年第8期|共7页
作者
Kensuke Kawara; Genichiro Tsuji; Yosuke Taniguchi; Shigeki Sasaki;
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作者单位

Graduate School of Pharmaceutical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 (Japan);

Graduate School of Pharmaceutical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 (Japan);

Graduate School of Pharmaceutical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 (Japan);

Graduate School of Pharmaceutical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 (Japan);

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原文格式 PDF
正文语种 eng
中图分类应用化学;
关键词
5helicene; B-Z transition; chirality; DNA; synchronization;

机译：[5] Helicene;B-Z过渡;手性;DNA;同步;

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专利

1. Synchronized Chiral Induction between [5]Helicene-Spermine Ligand and B-Z DNA Transition [J] . Kensuke Kawara, Genichiro Tsuji, Yosuke Taniguchi, Chemistry: A European journal . 2017,第8期

机译：[5]甲丙烯 - 精牙配体和B-Z DNA过渡之间的同步手性诱导
2. Enantioselective binding of chiral 1,14-dimethyl[5]helicene-spermine ligands with B- and Z-DNA [J] . TsujiG., KawakamiK., SasakiS. Bioorganic and medicinal chemistry . 2013,第19期

机译：手性1,14-二甲基[5]]烯-精胺配体与B-和Z-DNA的对映选择性结合
3. Ligand-controlled asymmetric induction at a transition metal-bonded alpha-carbon in ester and amide enolates. Diastereoselective formation of oxapalladacycles applied to the synthesis of a chiral nonracemic 2H-1-benzopyran [J] . Portscheller JL., Lilley SE., Malinakova HC. Organometallics . 2003,第14期

机译：酯和酰胺烯酸酯中过渡金属键合的α-碳上的配体控制的不对称感应。 oxapalladacycles的非对映选择性形成用于手性非外消旋2H-1-苯并吡喃的合成
4. 19F chemical shift detection of DNA B-Z transition using fluorine labeled pyrimidine [C] . Chen Wang, Hui Yang, Shigetaka Nakamura 日本化学会春季年会講演予稿集 . 2018

机译：19F使用氟标记嘧啶的DNA B-Z过渡的化学换档检测
5. Thermodynamic stability studies of B-Z junction-forming DNA oligomeric duplexes, and the effect of base pair A/C and G/T mismatches at or near the B-Z junction. [D] . Otokiti, Ebenezer O. 1998

机译：B-Z结形成DNA低聚物双链体的热力学稳定性研究，以及B-Z结处或附近碱基对A / C和G / T错配的影响。
6. Cooperative chiral order in the B-Z transition in random sequences of DNA. [O] . J V Selinger, J M Schnur 1997

机译：DNA随机序列中B-Z过渡的合作手性顺序。
7. Сhiral and Racemic Fields Concept for Understanding of the Homochirality Origin, Asymmetric Catalysis, Chiral Superstructure Formation from Achiral Molecules, and B-Z DNA Conformational Transition [O] . Valerii A. Pavlov, Yaroslav V. Shushenachev, Sergey G. Zlotin 2019

机译：Сhiral和外消旋领域的理念，了解众主学来源，非对称催化，从成立分子的手性上层建筑形成，以及B-Z DNA构象过渡

Synchronized Chiral Induction between [5]Helicene-Spermine Ligand and B-Z DNA Transition

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