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首页> 外文期刊>Chemistry: A European journal >Dinickel-Salphen Complexes as Binders of Human Telomeric Dimeric G-Quadruplexes
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Dinickel-Salphen Complexes as Binders of Human Telomeric Dimeric G-Quadruplexes

机译：Dinickel-Salphen复合物作为人端粒二聚体G-四边形的粘合剂

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摘要

Three new polyether-tethered dinickel-salphen complexes (2a-c) have been synthesized and fully characterized by NMR spectroscopy, mass spectrometry, and elemental analyses. The binding affinity and selectivity of these complexes and of the parent mono-nickel complex (1) towards dimeric quadruplex DNA have been determined by UV/Vis titrations, fluorescence spectroscopy, CD spectroscopy, and electrophoresis. These studies have shown that the dinickel-salphen complex with the longest polyether linker (2c) has higher binding affinity and selectivity towards dimeric quadruplexes (over monomeric quadruplexes) than the dinickel-salphen complexes with the shorter polyether linkers (2a and 2b). Complex 2c also has higher selectivity towards human telomeric dimeric quadruplexes with one TTA linker than the monometallic complex 1. Based on the spectroscopic data, a possible binding mode between complex 2c and the dimeric G-quadruplex DNA under study is proposed.
机译：已经合成了三种新的聚醚束缚的DINICKEL-酱油（2A-C）并通过NMR光谱，质谱和元素分析完全表征。 通过UV / VI滴定，荧光光谱，CD光谱和电泳，这些配合物和母体单镍复合物（1）的结合亲和力和选择性已经通过UV / Vis滴定，荧光光谱，CD光谱和电泳确定。 这些研究表明，具有最长聚醚接头（2C）的DINICKEL-酱油复合物具有比具有较短聚醚接头（2A和2B）的DINICK-Salphen络合物更高的结合亲和力和选择性朝向二聚体Quadreples（在单体四边形）中的结合亲和力和选择性。 复合物2C对具有比单金属络合物的人端粒二聚体四翻来的选择性高于单金属络合物1.基于光谱数据，提出了复合物2C与二聚体G-QuadrepleDNA之间的可能结合模式。

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  • 来源
    《Chemistry: A European journal》 |2017年第19期|共10页
  • 作者

    Chun-Qiong Zhou; Ting-Cong Liao; Zi-Qi Li; Jorge Gonzalez-Garcia; Matthew Reynolds; Min Zou; Ramon Vilar;

  • 作者单位

    Department of Chemistry Imperial College London South Kensington London SW72AZ (UK);

    Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 (P. R. China);

    Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 (P. R. China);

    Department of Chemistry Imperial College London South Kensington London SW72AZ (UK);

    Department of Chemistry Imperial College London South Kensington London SW72AZ (UK);

    Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 (P. R. China);

    Department of Chemistry Imperial College London South Kensington London SW72AZ (UK);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    dimeric quadruplex DNA; DNA recognition; metal salphen; telomere·nickel;

    机译：二聚体Quadreplex DNA;DNA识别;金属酱;端子·镍;

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