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首页> 外文期刊>Chemistry: A European journal >Supramolecular Hydrogels Based on Minimalist Amphiphilic Squaramide–Squaramates for Controlled Release of Zwitterionic Biomolecules
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Supramolecular Hydrogels Based on Minimalist Amphiphilic Squaramide–Squaramates for Controlled Release of Zwitterionic Biomolecules

机译：基于极简主义两亲鳞甲酰基苯胺的超分子水凝胶，用于两性离子生物分子控制释放的Squaramate

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摘要

Supramolecular hydrogels with tunable properties have innovative applications in biomedicine, catalysis, and materials chemistry. Minimalist low-molecular-weight hydrogelators based on squaramide and squaramic acid motifs have been designed. This approach benefits from the high acidity of squaramic acids and the aromaticity of squaramides. Moreover, substituents on the aryl ring tune the p density of the arylsquaramide motif. Thus, materials featuring distinct thermal and mechanical properties have been successfully prepared. The hydrogel (G’≈400 Pa, G’’≈57 Pa; at 1.0% w/v; 1 Hz) obtained from 4-nitrophenylsquaramide motif 1 is thermoreversible (T=57°C at 0.2% w/v), thixotropic, self-healable, and undergoes irreversible shrinking in response to saline stress. Furthermore, the hydrogel is injectable and can be loaded with substantial amounts (5:1 excess molar ratio) of zwitterionic biomolecules, such as l-carnitine, γ-aminobutyric acid (GABA), or d,l-Ala-d,l-Ala, without any loss of structural integrity. Then, the release of these molecules can be modulated by saline solutions.
机译：具有可调谐性质的超分子水凝胶在生物医学，催化和材料化学中具有创新应用。设计了基于Squaramide和Squaramic酸基序的极简主义低分子量水凝胶。这种方法受益于Squaramic酸的高酸度和Squaramides的芳香性。另外，芳基环序列的取代基曲调芳基喹啉基胺的P密度。因此，已经成功地制备了具有不同热和机械性能的材料。水凝胶（G'≈400Pa，G'''''≈57Pa; 1.0％w / v; 1 hz）由4-硝基苯基喹甲酰氨基甲酰胺1获得，热可逆（t = 57℃），触变分子响应盐胁迫，自我愈合，并经历不可逆转的萎缩。此外，水凝胶是可注射的，可以用两性离子生物分子的大量（5：1过量的摩尔比）加载，例如L-肉碱，γ-氨基丁酸（GABA），或D，L-ALA-D，L- ALA，没有任何结构完整性的损失。然后，可以通过盐水溶液调节这些分子的释放。

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  • 来源
    《Chemistry: A European journal》 |2017年第31期|共5页
  • 作者

    Carlos López; Marta Ximenis; Francisca Orvay; Carmen Rotger; Antonio Costa;

  • 作者单位

    Departament de Química Facultad de CiHncies Universitat de les Illes Balears Ctra. Valldemossa Km. 7.5 Palma 07122 (Spain);

    Departament de Química Facultad de CiHncies Universitat de les Illes Balears Ctra. Valldemossa Km. 7.5 Palma 07122 (Spain);

    Departament de Química Facultad de CiHncies Universitat de les Illes Balears Ctra. Valldemossa Km. 7.5 Palma 07122 (Spain);

    Departament de Química Facultad de CiHncies Universitat de les Illes Balears Ctra. Valldemossa Km. 7.5 Palma 07122 (Spain);

    Departament de Química Facultad de CiHncies Universitat de les Illes Balears Ctra. Valldemossa Km. 7.5 Palma 07122 (Spain);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    gels; noncovalent interactions; squaramides; supramolecular chemistry; zwitterions;

    机译：凝胶;非共价相互作用;Squaramides;超分子化学;两次;

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