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首页> 外文期刊>Chemistry: A European journal >The Lipid A from Rhodopseudomonas palustris Strain BisA53 LPS Possesses a Unique Structure and Low Immunostimulant Properties
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The Lipid A from Rhodopseudomonas palustris Strain BisA53 LPS Possesses a Unique Structure and Low Immunostimulant Properties

机译：来自RhodopseudomonasPalustris菌株Bisa53 LPS的脂质A具有独特的结构和低免疫刺激性

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摘要

The search for novel lipid A analogues from any biological source that can act as antagonists, displaying inhibitory activity towards the production of pro-inflammatory cytokines, or as immunomodulators in mammals, is a very topical issue. To this aim, the structure and immunological properties of the lipopolysaccharide lipid A from the purple nonsulfur bacterium Rhodopseudomonas palustris strain BisA53 have been determined. This lipid A displays a unique structural feature, with a non-phosphorylated skeleton made up of the tetrasaccharide Manp-α-(1→4)-GlcpN3N-β-1→6- GlcpN3N-α-(1→1)-α-GalpA, and four primary amide-linked 14:0(3-OH) and, as secondary O-acyl substituents, a 16:0 and the very long-chain fatty acid 26:0(25-OAc), appended on the GlcpN3N units. This lipid A architecture is definitely rare, so far identified only in the genus Bradyrhizobium. Immunological tests on both murine bone-marrow-derived and human monocyte-derived macrophages revealed an extremely low immunostimulant capability of this LPS lipid A.
机译：搜索来自任何可以充当拮抗剂的生物来源的新型脂质的类似物，显示抑制活动朝向哺乳动物中的促炎细胞因子的产生或作为免疫调节剂，是一个非常局部的问题。为此，已经确定了脂多糖脂质A来自紫色非硫酸菌罗二霉菌的结构和免疫学特性已经确定了Palustris菌株Bisa53。该脂质A显示出独特的结构特征，具有由四糖MANP-α-（1→4）-GLCPN3N-β-1→6-GLCPN3N-α-（1→1）-α-（1→1）-α-（1→1）-α-（1）的非磷酸化骨架Galpa和4个初级酰胺连接的14：0（3-OH），作为仲邻酰基取代基，A 16：0和非常长链脂肪酸26：0（25-OAC），附加在GLCPN3N上单位。这一脂质的建筑绝对是罕见的，到目前为止仅在Bradyrhizobium属中鉴定。鼠骨骨髓衍生和人单核细胞衍生的巨噬细胞的免疫检测显示出该LPS脂A的极低免疫增刺能力。

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  • 来源
    《Chemistry: A European journal》 |2017年第15期|共11页
  • 作者

    Flaviana Di Lorenzo; Angelo Palmigiano; Sami Al Bitar-Nehme; Luisa Sturiale; Katarzyna A. Duda; Djamel Gully; Rosa Lanzetta; Eric Giraud; Domenico Garozzo; Maria Lina Bernardini; Antonio Molinaro; Alba Silipo;

  • 作者单位

    Department of Chemical Sciences University of Naples Federico II via Cinthia 4 80126 Naples (Italy);

    CNR-Istituto per i Polimeri Compositi e Biomateriali IPCB-Unità di Catania Via Gaifami 18 95126 Catania (Italy);

    Dipartimento di Biologia e Biotecnologie "C. Darwin" Sapienza-Università di Roma Piazzale Aldo Moro 5 00185 Roma (Italy);

    CNR-Istituto per i Polimeri Compositi e Biomateriali IPCB-Unità di Catania Via Gaifami 18 95126 Catania (Italy);

    Junior Group of Allergobiochemistry Research Center Borstel Leibniz-Center for Medicine and Biosciences 23845 Borstel Airway Research Center North (ARCN) German Center for Lung Research (Germany);

    IRD Laboratoire des Symbioses Tropicales et Méditerranéennes UMR IRD/SupAgro/INRA/UM2/CIRAD Campus International de Baillarguet TA A-82/J 34398 Montpellier Cedex 5 (France);

    Department of Chemical Sciences University of Naples Federico II via Cinthia 4 80126 Naples (Italy);

    IRD Laboratoire des Symbioses Tropicales et Méditerranéennes UMR IRD/SupAgro/INRA/UM2/CIRAD Campus International de Baillarguet TA A-82/J 34398 Montpellier Cedex 5 (France);

    CNR-Istituto per i Polimeri Compositi e Biomateriali IPCB-Unità di Catania Via Gaifami 18 95126 Catania (Italy);

    Dipartimento di Biologia e Biotecnologie "C. Darwin" Sapienza-Università di Roma Piazzale Aldo Moro 5 00185 Roma (Italy);

    Department of Chemical Sciences University of Naples Federico II via Cinthia 4 80126 Naples (Italy);

    Department of Chemical Sciences University of Naples Federico II via Cinthia 4 80126 Naples (Italy);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    fatty acids; glycolipids; innate immunity; lipopolysaccharides; NMR spectroscopy;

    机译：脂肪酸;糖脂;先天免疫;脂多糖;NMR光谱;

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