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Recent Advances in the Chemistry and Biology of Podophyllotoxins

机译：疣毒素化学与生物学的最新进展

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摘要

Podophyllotoxin and its related aryltetralin cyclolignans belong to a family of important products that exhibit various biological properties (e.g., cytotoxic, insecticidal, antifungal, antiviral, anti-inflammatory, neurotoxic, immunosuppressive, antirheumatic, antioxidative, antispasmogenic, and hypolipidemic activities). This Review provides a survey of podophyllotoxin and its analogues isolated from plants. In particular, recent developments in the elegant total chemical synthesis, structural modifications, biosynthesis, and biotransformation of podophyllotoxin and its analogues are summarized. Moreover, a deoxypodophyllotoxin-based chemosensor for selective detection of mercury ion is described. In addition to the most active podophyllotoxin derivatives in each series against human cancer cell lines and insect pests listed in the tables, the structure-activity relationships of podophyllotoxin derivatives as cytotoxic and insecticidal agents are also outlined. Future prospects and further developments in this area are covered at the end of the Review. We believe that this Review will provide necessary information for synthetic, medicinal, and pesticidal chemistry researchers who are interested in the chemistry and biology of podophyllotoxins.
机译：毒鼠毒素及其相关的芳基图谱环荷族人属于一个具有各种生物特性的重要产品（例如，细胞毒性，杀虫，抗真菌，抗病毒，抗炎，神经毒性，免疫抑制，抗逆肿瘤，抗氧化，抗痉挛和低血散活性）。该综述提供了对植物中分离的鼠毒素毒素及其类似物的调查。特别是，总结了近期化学合成，结构修饰，生物合成和鼠毒素毒素及其类似物的总体化学合成，结构修饰，生物转化的发展。此外，描述了一种用于选择性检测汞离子的基于脱氧基霉毒素的化学传感器。除了针对人类癌细胞系和表中列出的人类癌细胞系和昆虫害虫中最活跃的鼠毒素毒素衍生物外，还概述了阴道毒素衍生物作为细胞毒性和杀虫剂的结构 - 活性关系。未来的前景和该地区的进一步发展在审查结束时涵盖。我们认为，本综述将为对鼠毒素毒素的化学和生物学感兴趣的合成，药用和杀虫化学研究人员提供必要的信息。

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  • 来源
    《Chemistry: A European journal》 |2017年第19期|共60页
  • 作者

    Xiang Yu; Zhiping Che; Hui Xu;

  • 作者单位

    Research Institute of Pesticidal Design and Synthesis College of Plant Protection/Sciences Northwest A&

    F University Yangling 712100 Shaanxi Province (P.R. China);

    Research Institute of Pesticidal Design and Synthesis College of Plant Protection/Sciences Northwest A&

    F University Yangling 712100 Shaanxi Province (P.R. China);

    Research Institute of Pesticidal Design and Synthesis College of Plant Protection/Sciences Northwest A&

    F University Yangling 712100 Shaanxi Province (P.R. China);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    biological property; biosynthesis; podophyllotoxin; structural modification; total chemical synthesis;

    机译：生物学性质;生物合成;波脱毒素;结构改性;总化学合成;

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