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Peptide-Based Molecular Hydrogels as Supramolecular Protein Mimics

机译：基于肽的分子水凝胶作为超分子蛋白质模拟物

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摘要

This Minireview concerns recent advances in the design, synthesis, and application of low molecular-weight peptidic hydrogelators. The sequence-specific combinations of amino acid side chain functionalities combined with hydrogen bonding of amide backbones and hydrophobic (aromatic) capping groups give these peptidic molecules the intrinsic tendency to self-assemble. The most prevalent designs include N-capped amino acid residues, bolamphiphilic peptides, and amphipathic peptides. Factors such as hydrophobic effects, the Hofmeister effect, and tunable ionization influence their aggregation properties. The self-assembly of simple bio-inspired building blocks into higher organized structures allows comparisons to be drawn with proteins and their complex functionalities, providing preliminary insights into complex biological functions and also enabling their application in a wide range of fields including catalysis, biomedical applications, and mimicry of natural dissipative systems. The Minireview is concluded by a short summary and outlook, highlighting the advances and steps required to bridge the gaps in the understanding of such systems.
机译：该MiniView涉及低分子量肽水蛋白的设计，合成和应用的最新进展。氨基酸侧链官能团的序列特异性组合与酰胺骨干和疏水性（芳族）封端基团的氢键合并，使这些肽分子自组装的内在倾向。最普遍的设计包括N-CAPPED氨基酸残基，乌贼肽和两亲性肽。疏水效应，HoFmeister效应和可调谐电离等因素影响它们的聚集性能。简单生物启发基层的自组装成更高的组织结构允许使用蛋白质和复杂功能来吸取比较，从而为复杂的生物学功能提供初步见解，并使它们在包括催化作用，生物医学应用的广泛领域中的应用以及天然耗散系统的模仿。 MINIREVIEW由简短的摘要和前景结束，突出了弥合在理解这些系统的情况下弥合差距所需的进展和步骤。

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  • 来源
    《Chemistry: A European journal》 |2017年第5期|共13页
  • 作者

    Nishant Singh; Mohit Kumar; Juan F. Miravet; Rein V. Ulijn; Beatriu Escuder;

  • 作者单位

    Departament de Química Inorg/nica i Org/nica Universitat Jaume I Av. Sos Baynat s/n 12071 Castellj (Spain);

    Advanced Science Research Centre (ASRC) City University of New York 85 St Nicholas Terrace New York NY 10031 (USA);

    Departament de Química Inorg/nica i Org/nica Universitat Jaume I Av. Sos Baynat s/n 12071 Castellj (Spain);

    Advanced Science Research Centre (ASRC) City University of New York 85 St Nicholas Terrace New York NY 10031 (USA);

    Departament de Química Inorg/nica i Org/nica Universitat Jaume I Av. Sos Baynat s/n 12071 Castellj (Spain);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    biomaterials; gels; peptides; self-assembly; supramolecular chemistry;

    机译：生物材料;凝胶;肽;自组装;超分子化学;

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