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A Fluorine-18 Radiolabeling Method Enabled by Rhenium(I) Complexation Circumvents the Requirement of Anhydrous Conditions

机译:通过铼(I)络合使能的氟-18放射性标记方法避免无水条件的要求

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摘要

Azeotropic distillation is typically required to achieve fluorine-18 radiolabeling during the production of positron emission tomography (PET) imaging agents. However, this time-consuming process also limits fluorine- 18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations, the fluorine-18 radiolabeling of one model rhenium(I) complex is reported here, which is significantly improved under conditions that do not require azeotropic drying. This work could open a route towards the investigation of a simplified metal-mediated late-stage radiofluorination method, which would expand upon the accessibility of new PET and PET-optical probes.
机译:通常需要共沸蒸馏来在正电子发射断层扫描(PET)成像剂的生产过程中实现氟-18放射性标记。 然而,由于同位素的放射性衰减及其对干燥容器的吸附,这种耗时的过程也限制了氟-18掺入。 在解决这些限制时,这里据报道一种模型铼(I)复合物的氟-18放射性标记,在不需要共沸干燥的条件下显着改善。 这项工作可以开通探讨简化金属介导的后级无线电氟化方法的途径,这将扩大新PET和PET-光学探针的可达性。

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  • 来源
    《Chemistry: A European journal》 |2017年第27期|共5页
  • 作者单位

    Australian Nuclear Science and Technology Organisation (ANSTO) New Illawarra Rd Lucas Heights New South Wales (Australia);

    Australian Nuclear Science and Technology Organisation (ANSTO) New Illawarra Rd Lucas Heights New South Wales (Australia);

    Australian Nuclear Science and Technology Organisation (ANSTO) New Illawarra Rd Lucas Heights New South Wales (Australia);

    Australian Nuclear Science and Technology Organisation (ANSTO) New Illawarra Rd Lucas Heights New South Wales (Australia);

    School of Science and Health Western Sydney University Penrith New South Wales (Australia);

    Australian Nuclear Science and Technology Organisation (ANSTO) New Illawarra Rd Lucas Heights New South Wales (Australia);

    School of Science and Health Western Sydney University Penrith New South Wales (Australia);

    Australian Nuclear Science and Technology Organisation (ANSTO) New Illawarra Rd Lucas Heights New South Wales (Australia);

    Brain and Mind Centre The University of Sydney Mallett St Camperdown New South Wales (Australia);

    Department of Chemistry Curtin University Kent St Bentley Western Australia (Australia);

    Australian Nuclear Science and Technology Organisation (ANSTO) New Illawarra Rd Lucas Heights New South Wales (Australia);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    fluorine-18 radiolabeling; late-stage fluorination; microfluidics; pet chemistry; rhenium complexes;

    机译:氟-18放射性标记;晚期氟化;微流体;宠物化学;铼络合物;

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