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首页> 外文期刊>Chemistry: A European journal >Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials
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Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials

机译：环糊精纳米粒子轴承8-羟基喹啉配体作为多功能生物材料

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Cyclodextrins are used as building blocks for the development of a host of polymeric biomaterials. The cyclodextrin polymers have found numerous applications as they exhibit unique features such as mechanical properties, stimuli responsiveness and drug loading ability. Notwithstanding the abundance of cyclodextrin polymers studied, metal-chelating polymers based on cyclodextrins have been poorly explored. Herein we report the synthesis and the characterization of the first metal-chelating b-cyclodextrin polymer bearing 8-hydroxyquinoline ligands. The metal ions (Cu~(2+) or Zn~(2+)) can modulate the assembly of the polymer nanoparticles. Moreover, the protective activity of the new chelating polymer against self- and metal-induced Ab aggregation and free radical species are significantly higher than those of the parent compounds. These synergistic effects suggest that the incorporation of hydroxyquinoline moieties into a soluble b-cyclodextrin polymer could represent a promising strategy to design multifunctional biomaterials.
机译：环糊精用作开发一系列聚合物生物材料的构建块。环糊精聚合物已发现许多应用，因为它们表现出独特的特征，例如机械性能，刺激反应性和药物负载能力。尽管有丰富的环糊精聚合物，但基于环糊精的金属螯合聚合物探索着较差。在此，我们报告了第一金属螯合B-环糊精聚合物轴承8-羟基喹啉配体的合成和表征。金属离子（Cu〜（2+）或Zn〜（2+）可以调节聚合物纳米颗粒的组装。此外，新的螯合聚合物对自来和金属诱导的AB聚集和自由基物质的保护活性显着高于母体化合物。这些协同作用表明将羟基喹啉部分掺入可溶性B-环糊精聚合物中，可以代表设计多功能生物材料的有希望的策略。

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