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首页> 外文期刊>Chemistry: A European journal >Artificial Enzyme-based Logic Operations to Mimic an Intracellular Enzyme-participated Redox Balance System
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Artificial Enzyme-based Logic Operations to Mimic an Intracellular Enzyme-participated Redox Balance System

机译：基于人工酶的逻辑操作，用于模拟细胞内酶参与的氧化还原系统

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摘要

Owing to the biocatalytic properties of artificial enzymes and the redox characteristic of glutathione, a colorimetric and resettable biological operation was successfully designed to mimic enzyme-participated redox balance in living systems. As one promising candidate of a natural enzyme, artificial enzyme possesses many advantages and has been used in numerous fields. Similar to natural enzymes, communications are also present between different artificial enzymes. With the assistance of four artificial enzymes, three simple biological logic gates were fabricated to help us deepen the understanding of communications between artificial enzymes. In the presence of glutathione, the system could be easily reset without any complicated procedures. We prospect that this work may push forward the exploration of communications between different artificial enzymes and the design of novel artificial enzyme-based biological gates or nanodevices. We hope that our mimic system may help us further understand the functioning of complex biological pathways in biological systems.
机译：由于人工酶的生物催化性能和谷胱甘肽的氧化还原性能，成功设计了比色和可重置的生物操作，以模仿酶参与生活系统中的氧化还原平衡。作为天然酶的一个有希望的候选者，人工酶具有许多优点并且已在许多领域中使用。类似于天然酶，通信也存在于不同的人造酶之间。在四个人工酶的帮助下，制造了三个简单的生物逻辑门，以帮助我们加深对人工酶之间的通信的理解。在谷胱甘肽的存在下，系统可以容易地重置而没有任何复杂的程序。我们展望这项工作可能推进对不同人工酶与新型人工酶的生物栅极或纳米型设计之间的通信探索。我们希望我们的模仿系统可以帮助我们进一步了解生物系统中复杂生物途径的运作。

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  • 来源
    《Chemistry: A European journal》 |2017年第38期|共6页
  • 作者

    Yanyan Huang; Fang Pu; Jinsong Ren; Xiaogang Qu;

  • 作者单位

    Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin 130022 (P. R. China);

    Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin 130022 (P. R. China);

    Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin 130022 (P. R. China);

    Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin 130022 (P. R. China);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用化学;
  • 关键词

    enzymes; glutathione; logic gates; redox chemistry; ROS;

    机译：酶;谷胱甘肽;逻辑门;氧化还原化学;ROS;

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