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首页> 外文期刊>Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides >Cross-linking of dialdehyde carboxymethyl cellulose with silk sericin to reinforce sericin film for potential biomedical application
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Cross-linking of dialdehyde carboxymethyl cellulose with silk sericin to reinforce sericin film for potential biomedical application

机译：用丝丝蛋白的二醛羧甲基纤维素的交联促进潜在生物医学应用的硅膜膜

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摘要

Developing biomaterials based on the natural biomacromolecule silk sericin from Bombyx mori cocoon is of great interest for biomedical application. Dialdehyde carboxymethyl cellulose (DCMC) is derived from periodate oxidation of carboxy-methyl cellulose. Here, we developed a novel strategy of cross-linking of sericin with DCMC via the Schiff's base reaction. Fourier transform infrared spectroscopy and scanning electron microscopy indicated the formation of Schiff's base via the blending of sericin and DCMC. The mechanical properties tests suggested the covalent cross-linking effectively enhanced the tensile strength of sericin. The swelling test and water contact angle indicated the DCMC/SS film had excellent hydrophilicity, swellability. Additionally, we demonstrated the DCMC/SS film had excellent blood compatibility, cytocompatibility and promoting cell proliferation activity by the hemolysis ratio analysis, cell adhesion, cells viability and proliferation assays. The prepared DCMC/SS film has shown great promise in biomedical applications such as wound dressing, artificial skin and tissue engineering.
机译：基于Bombyx Mori Cocoon的天然生物摩洛丝丝素的发展生物材料对生物医学应用感兴趣。二醛羧甲基纤维素（DCMC）衍生自羧基 - 甲基纤维素的周期氧化。在这里，我们通过Schiff的基础反应开发了一种用DCMC交联的三种交联策略。傅里叶变换红外光谱和扫描电子显微镜表明，通过硅蛋白和DCMC的混合形成了Schiff基地的形成。机械性能试验表明共价交联有效增强了丝裂蛋白的拉伸强度。溶胀试验和水接触角表示DCMC / SS膜具有优异的亲水性，溶胀性。另外，我们证明了DCMC / SS薄膜通过溶血比分析，细胞粘附，细胞活力和增殖测定具有优异的血液相容性，细胞相容性和促进细胞增殖活性。准备好的DCMC / SS薄膜在伤口敷料，人造皮肤和组织工程等生物医学应用中表现出很大的希望。

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