Hyperpolarization-activated Cyclic Nucleotide-gated Channels May Contribute to Regional Anesthetic Effects of Lidocaine

Zhou Cheng; Ke Bowen; Zhao Yi; Liang Peng; Liao Daqing; Li Tao; Liu Jin; Chen Xiangdong

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Hyperpolarization-activated Cyclic Nucleotide-gated Channels May Contribute to Regional Anesthetic Effects of Lidocaine

机译：超极化激活的环核苷酸门控通道可能有助于利多卡因的区域麻醉作用

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Background: Local anesthetics (e.g., lidocaine) have been found to inhibit hyperpolarization-activated cyclic nucleotide-gated (HCN) channels besides sodium channels. However, the exact role of HCN channels in regional anesthesia in vivo is still elusive.

机译：背景：已经发现局部麻醉剂（例如利多卡因）除了抑制钠通道外，还可以抑制超极化激活的环状核苷酸门控（HCN）通道。但是，HCN通道在体内区域麻醉中的确切作用仍然难以捉摸。

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《Anesthesiology》 |2015年第3期|共13页
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Zhou Cheng; Ke Bowen; Zhao Yi; Liang Peng; Liao Daqing; Li Tao; Liu Jin; Chen Xiangdong;
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正文语种 eng
中图分类麻醉学;
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1. Hyperpolarization-activated Cyclic Nucleotide-gated Channels May Contribute to Regional Anesthetic Effects of Lidocaine [J] . Zhou Cheng, Ke Bowen, Zhao Yi, Anesthesiology . 2015,第3期

机译：超极化激活的环核苷酸门控通道可能有助于利多卡因的区域麻醉作用
2. Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts. [J] . Fernandez Velasco M, Goren N, Benito G, The Journal of Physiology . 2003,第Pta2期

机译：对照和肥大大鼠心脏的心室细胞中超极化激活电流（If）和超极化激活环核苷酸门控通道mRNA表达的区域分布。
3. Hyperpolarization-activated cyclic nucleotide-gated channels contribute to spontaneous activity in L4 C-fiber nociceptors, but not A beta-non-nociceptors, after axotomy of L5-spinal nerve in the rat in vivo [J] . Djouhri Laiche, Smith Trevor, Ahmeda Ahmad, Pain. . 2018,第7期

机译：超极化激活的循环核苷酸门控通道有助于L4 C-纤维伤害者的自发性活性，但不是β-非伤害者在体内大鼠L5脊神经的腋窝后
4. A Role for Cyclic Nucleotide-Gated Channels in the Capacitation of Mammalian Sperm [C] . Cisneros-Mejorado A. Sanchez D Western Pharmacology Society . 2011

机译：循环核苷酸门控通道在哺乳动物精子的电容中的作用
5. Trigeminal Neuropathic Pain in Rats: A Role for Thalamic Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Activity [D] . Doheny, Jason. 2020

机译：大鼠的三叉神经疗法疼痛：对丘脑超极化活性的循环核苷酸门控通道活性的作用
6. Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts [O] . María Fernández-Velasco, Nora Goren, Gemma Benito, 2003

机译：对照和肥大大鼠心脏的心室细胞中超极化激活电流（If）和超极化激活环核苷酸门控通道mRNA表达的区域分布
7. Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts [O] . Fernández-Velasco, María, Goren, Nora, Benito, Gemma, 2013

机译：对照和肥大大鼠心脏的心室细胞中超极化激活电流（If）和超极化激活环核苷酸门控通道mRNA表达的区域分布
8. Cyclic Nucleotide-Gated Electrical Activity in Olfactory Receptor Cells. [R] . Vodyanoy, V. 1989

机译：嗅觉受体细胞中的环核苷酸门控电活动。

Hyperpolarization-activated Cyclic Nucleotide-gated Channels May Contribute to Regional Anesthetic Effects of Lidocaine

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