ACTG A5353: A Pilot Study of Dolutegravir Plus Lamivudine for Initial Treatment of Human Immunodeficiency Virus-1 (HIV-1)–infected Participants With HIV-1 RNA <500000 Copies/mL

Babafemi OTaiwo; LuZheng; AndreiStefanescu; AmesikaNyaku; BaibaBezins; Carole LWallis; CatherineGodfrey; Paul ESax; EdwardAcosta; DavidHaas; Kimberly YSmith; BeverlySha; CorneliusVan Dam; Roy MGulick

首页> 外文期刊>Clinical infectious diseases >ACTG A5353: A Pilot Study of Dolutegravir Plus Lamivudine for Initial Treatment of Human Immunodeficiency Virus-1 (HIV-1)–infected Participants With HIV-1 RNA <500000 Copies/mL

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ACTG A5353: A Pilot Study of Dolutegravir Plus Lamivudine for Initial Treatment of Human Immunodeficiency Virus-1 (HIV-1)–infected Participants With HIV-1 RNA <500000 Copies/mL

机译：ACTG A5353：DoluteGravir Plus Lamivudine的试验研究，用于初始治疗人免疫缺陷病毒-1（HIV-1） - 培养的参与者的HIV-1 RNA <500000拷贝/ mL

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Dolutegravir plus lamivudine was virologically effective and safe in treatment-naive individuals with human immunodeficiency virus type 1 RNA up to 500 000 copies/mL. A participant who experienced failure developed the M184V lamivudine and the R263R/K integrase resistance mutations.

机译：Dolutegravir Plus Lamivudine在治疗 - 幼稚动物中是病毒性有效和安全的，人类免疫缺陷病毒1型RNA高达500000拷贝/ mL。经历了失败的参与者开发了M184V拉米夫定和R263R / K整合酶电阻突变。

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来源
《Clinical infectious diseases》 |2018年第11期|共9页
作者
Babafemi OTaiwo; LuZheng; AndreiStefanescu; AmesikaNyaku; BaibaBezins; Carole LWallis; CatherineGodfrey; Paul ESax; EdwardAcosta; DavidHaas; Kimberly YSmith; BeverlySha; CorneliusVan Dam; Roy MGulick;
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正文语种 eng
中图分类传染病;
关键词
dolutegravir; lamivudine; 2-drug therapy; mutation; naive;

机译：多杜特格拉维尔;拉米夫定;2药物治疗;突变;天真;

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1. ACTG A5353: A Pilot Study of Dolutegravir Plus Lamivudine for Initial Treatment of Human Immunodeficiency Virus-1 (HIV-1)–infected Participants With HIV-1 RNA <500000 Copies/mL [J] . Babafemi OTaiwo, LuZheng, AndreiStefanescu, Clinical infectious diseases . 2018,第11期

机译：ACTG A5353：DoluteGravir Plus Lamivudine的试验研究，用于初始治疗人免疫缺陷病毒-1（HIV-1） - 培养的参与者的HIV-1 RNA <500000拷贝/ mL
2. Treatment-Induced Decline of Human Immunodeficiency Virus-1 p24 and HIV-1 RNA in Lymphoid Tissue of Patients with Early Human Immunodeficiency Virus-1 Infection [J] . Herbert Kuster, Milos Opravil, Peter Ott, American Journal of Pathology . 2000,第6期

机译：早期人类免疫缺陷病毒1感染患者淋巴组织中治疗诱导的人类免疫缺陷病毒1 p24和HIV-1 RNA下降
3. Cost-effectiveness and budget impact of dolutegravir/lamivudine for treatment of human immunodeficiency virus (HIV-1) infection in the United States [J] . Karin Butler, Sarah-Jane Anderson, Olivia Hayward, Journal of Managed Care & Specialty Pharmacy . 2021,第7期

机译：Dolutegravir / Lamivudine治疗人类免疫缺陷病毒（HIV-1）感染的成本效益和预算影响
4. Simultaneous extraction of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) RNA with the M1000 apparatus does not impair the measurement of the viral load of both viruses when tested by using the LCx PCR system [C] . T. Bourlet, S. Thamm, S. Pillet, European Congress of Virology . 2004

机译：通过使用LCX PCR系统测试，同时提取人免疫缺陷病毒类型1（HIV-1）和丙型肝炎病毒（HCV）RNA，不会损害两种病毒的病毒载量的测量
5. Studies of blood monocytes from patients infected with the human immunodeficiency virus-1 (HIV-1) [D] . Shen, Yuenan. 1991

机译：来自感染人类免疫缺陷病毒1（HIV-1）的患者血液单核细胞的研究
6. ACTG A5353: A Pilot Study of Dolutegravir Plus Lamivudine for Initial Treatment of Human Immunodeficiency Virus-1 (HIV-1)–infected Participants With HIV-1 RNA 500000 Copies/mL [O] . Babafemi O Taiwo, Lu Zheng, Andrei Stefanescu, -1

机译：ACTG A5353：Dolutegravir和Lamivudine初步治疗人类免疫缺陷病毒-1（HIV-1）感染的HIV-1 RNA 500000拷贝/毫升的参与者的初步研究
7. Dolutegravir–lamivudine as initial therapy in HIV-1 infected, ARV-naive patients, 48-week results of the PADDLE (Pilot Antiretroviral Design with Dolutegravir LamivudinE) study [O] . Pedro Cahn, María José Rolón, María Inés Figueroa, 2017

机译：Dolutegravir-lamivudine作为HIV-1感染，aRV初治患者的初始治疗，paDDLE的48周结果（polute antiretroviral Design with Dolutegravir LamivudinE）研究
8. Low Prevalence of Human Immunodeficiency Virus-1 (HIV-1), HIV-2, and Human T CellLymphotropic Virus-1 Infection in Somalia [R] . Scott, D. A., Corwin, A. L., Constantine, N. T., 1991

机译：索马里人类免疫缺陷病毒-1（HIV-1），HIV-2和人类T细胞淋巴细胞病毒-1感染的低患病率

ACTG A5353: A Pilot Study of Dolutegravir Plus Lamivudine for Initial Treatment of Human Immunodeficiency Virus-1 (HIV-1)–infected Participants With HIV-1 RNA <500000 Copies/mL

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