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The mouse as a model for neuropsychiatric drug development

机译：鼠标作为神经精神药物发育的模型

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摘要

Much has been written about the validity of mice as a preclinical model for brain disorders. Critics cite numerous examples of apparently effective treatments in mouse models that failed in human clinical trials, raising the possibility that the two species’ neurobiological differences could explain the high translational failure rate in psychiatry and neurology (neuropsychiatry). However, every stage of translation is plagued by complex problems unrelated to neurobiological conservation. Therefore, although these case studies are intriguing, they cannot alone determine whether these differences observed account for translation failures. Our analysis of the literature indicates that most neuropsychiatric treatments used in humans are at least partially effective in mouse models, suggesting that neurobiological differences are unlikely to be the main cause of neuropsychiatric translation failures.
机译：已经写了关于小鼠的有效性作为脑疾病的临床前模型。 批评者引用了许多在人类临床试验中失败的小鼠模型中明显有效治疗的实例，提高了两种物种的神经生物学差异可以解释精神病学和神经病学（神经精神）的高转化失败率的可能性。 然而，每个翻译阶段被与神经生物学保护无关的复杂问题困扰。 因此，虽然这些案例研究是有趣的，但它们不能单独确定这些差异是否观察到翻译失败。 我们对文献的分析表明，人类使用的大多数神经精神治疗在小鼠模型中至少部分有效，表明神经生物学差异不太可能成为神经精神转化失败的主要原因。

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  • 来源
    《Current Biology: CB》 |2018年第17期|共6页
  • 作者

    James R. Howe; Mark F. Bear; Peyman Golshani; Eric Klann; Stuart A. Lipton; Lennart Mucke; Mustafa Sahin; Alcino J. Silva;

  • 作者单位

    Departments of Neurobiology Psychiatry &

    Biobehavioral Sciences and Psychology Integrative Center for Learning and Memory Brain Research Institute University of California Los Angeles;

    Picower Institute for Learning and Memory Department of Brain and Cognitive Sciences Massachusetts Institute of Technology;

    Departments of Neurology Psychiatry and Biobehavioral Sciences Integrative Center for Learning and Memory Brain Research Institute University of California;

    Center for Neural Science New York University;

    Neuroscience Translational Center and Departments of Molecular Medicine and Neuroscience The Scripps Research Institute La Jolla CA 92037 and Department of Neurosciences University of California;

    Gladstone Institute of Neurological Disease and Department of Neurology University of California San Francisco;

    F.M. Kirby Neurobiology Center Translational Neuroscience Center Department of Neurology Boston Children’s Hospital Harvard Medical School;

    Departments of Neurobiology Psychiatry &

    Biobehavioral Sciences and Psychology Integrative Center for Learning and Memory Brain Research Institute University of California Los Angeles;

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