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首页> 外文期刊>Current Biology: CB >Hexadirectional Modulation of Theta Power in Human Entorhinal Cortex during Spatial Navigation
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Hexadirectional Modulation of Theta Power in Human Entorhinal Cortex during Spatial Navigation

机译：空间导航期间人体onororlinal皮层中θ功率的海方调制

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摘要

Grid cells and theta oscillations are fundamental components of the brain’s navigation system. Grid cells provide animals [] and humans [] with a spatial map of the environment by exhibiting multiple firing fields arranged in a regular grid of equilateral triangles. This unique firing pattern presumably constitutes the neural basis for path integration [] and may also enable navigation in visual and conceptual spaces []. Theta frequency oscillations are a prominent mesoscopic network phenomenon during navigation in both rodents and humans [] and encode movement speed [], distance traveled [], and proximity to spatial boundaries []. Whether theta oscillations may also carry a grid-like signal remains elusive, however. Capitalizing on previous fMRI studies revealing a macroscopic proxy of sum grid cell activity in human entorhinal cortex (EC) [], we examined intracranial EEG recordings from the EC of epilepsy patients (n?= 9) performing a virtual navigation task. We found that the power of theta oscillations (4–8?Hz) exhibits 6-fold rotational modulation by movement direction, reminiscent of grid cell-like representations detected using fMRI. Modulation of theta power was specific to 6-fold rotational symmetry and to the EC. Hexadirectional modulation of theta power by movement direction only emerged during fast movements, stabilized over the course of the experiment, and showed sensitivity to the environmental boundary. Our results suggest that oscillatory power in the theta frequency range carries an imprint of sum grid cell activity potentially enabled by a common grid orientation of neighboring grid cells [].
机译：网格细胞和θ振荡是大脑导航系统的基本组件。网格细胞通过展示在等边三角形的常规网格中布置的多个烧制场，提供动物[]和人类[]用环境的空间图。这种独特的触发模式可能会构成路径集成的神经基础[]，也可以在视觉和概念空间中启用导航[]。在啮齿动物和人类[]和编码移动速度[]，行进[]的距离和空间边界附近，频率振荡是一种突出的介于介乎介乎介乎介乎介的网络现象，以及对空间边界的距离[]。然而，Theta振荡还可以承载网格状信号仍然难以捉摸。利用以前的FMRI研究，揭示人体Entorhinal Cortex（EC）[]中总结综合细胞活性的宏观研究，我们检查了癫痫患者EC的颅内EEG记录（n？= 9）执行虚拟导航任务。我们发现，Theta振荡的功率（4-8·Hz）通过移动方向表现出6倍的旋转调制，使使用FMRI检测到的网格电池状表示。 θ功率的调制特异于6倍的旋转对称性和EC。在快速运动期间仅出现通过移动方向的θ功率的海方调制，在实验过程中稳定，并对环境边界表示敏感性。我们的研究结果表明，θ频率范围内的振荡电力携带潜在地通过相邻网格单元的公共网格取向来实现的总和网格单元活动的压印。

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  • 来源
    《Current Biology: CB》 |2018年第20期|共10页
  • 作者

    Dong Chen; Lukas Kunz; Wenjing Wang; Hui Zhang; Wen-Xu Wang; Andreas Schulze-Bonhage; Peter C. Reinacher; Wenjing Zhou; Shuli Liang; Nikolai Axmacher; Liang Wang;

  • 作者单位

    School of Systems Science Beijing Normal University;

    Epilepsy Center Medical Center—University of Freiburg Faculty of Medicine University of Freiburg;

    School of Systems Science Beijing Normal University;

    Department of Neuropsychology Institute of Cognitive Neuroscience Faculty of Psychology Ruhr University Bochum;

    School of Systems Science Beijing Normal University;

    Epilepsy Center Medical Center—University of Freiburg Faculty of Medicine University of Freiburg;

    University Medical Center Stereotactic and Functional Neurosurgery;

    Department of Epilepsy Center Tsinghua University Yuquan Hospital;

    Department of Neurosurgery First Affiliated Hospital of General Hospital of PLA;

    Department of Neuropsychology Institute of Cognitive Neuroscience Faculty of Psychology Ruhr University Bochum;

    CAS Key Laboratory of Mental Health Institute of Psychology;

    CAS Center for Excellence in Brain Science and Intelligence Technology;

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  • 中图分类 生物科学;
  • 关键词

    theta; grid cell; navigation; intracranial EEG; oscillation; entorhinal cortex;

    机译：Theta;网格单元;导航;颅内脑电图;振荡;Entorhinal Cortex;

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