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首页> 外文期刊>Current Biology: CB >Acclimation of Oxygenic Photosynthesis to Iron Starvation Is Controlled by the sRNA IsaR1
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Acclimation of Oxygenic Photosynthesis to Iron Starvation Is Controlled by the sRNA IsaR1

机译：对铁饥饿的含氧光合作用的适应性由SRNA Isar1控制

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摘要

Oxygenic photosynthesis crucially depends on proteins that possess Fe (2+) or Fe/S complexes as co-factors or prosthetic groups. Here, we show that the small regulatory RNA (sRNA) IsaR1 (Iron-Stress-Activated RNA 1) plays a pivotal role in acclimation to low-iron conditions. The IsaR1 regulon consists of more than 15 direct targets, including Fe (2+)-containing proteins involved in photosynthetic electron transfer, detoxification of anion radicals, citrate cycle, and tetrapyrrole biogenesis. IsaR1 is essential for maintaining physiological levels of Fe/S cluster biogenesis proteins during iron deprivation. Consequently, IsaR1 affects the acclimation of the photosynthetic apparatus to iron starvation at three levels: (1) directly, via posttranscriptional repression of gene expression; (2) indirectly, via suppression of pigment; and (3) Fe/S cluster biosynthesis. Homologs of IsaR1 are widely conserved throughout the cyanobacterial phylum. We conclude that IsaR1 is a critically important riboregulator. These findings provide a new perspective for understanding the regulation of iron homeostasis in photosynthetic organisms.
机译：含氧光合作用是至关重要的，取决于具有Fe（2+）或Fe / S复合物作为共源或假体组的蛋白质。在这里，我们表明小型调节RNA（SRNA）ISAR1（铁 - 应力激活的RNA 1）在适应于低铁条件下起着枢转作用。 ISAR1 Securancon由15个以上的直接靶标，包括含有Fe（2 +）的蛋白质，涉及光合电子转移，阴离子自由基的解毒，柠檬酸盐循环和四吡咯生物发生。 ISAR1对于在铁剥夺期间维持Fe / S簇生物发生蛋白的生理水平至关重要。因此，ISAR1影响光合液在三个水平的熨烫饥饿的适应：（1）通过后颅面抑制基因表达; （2）间接，通过抑制颜料; （3）Fe / s群体生物合成。 ISAR1的同源物在整个蓝杆菌门中被广泛保守。我们得出结论，ISAR1是一个批判性重要的核电图。这些发现提供了一种了解理解光合生物中铁稳态的调控。

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  • 来源
    《Current Biology: CB》 |2017年第10期|共19页
  • 作者

    Georg Jens; Kostova Gergana; Vuorijoki Linda; Schoen Verena; Kadowaki Taro; Huokko Tuomas; Baumgartner Desiree; Mueller Maximilian; Klaehn Stephan; Allahverdiyeva Yagut; Hihara Yukako; Futschik Matthias E.; Aro Eva-Mari; Hess Wolfgang R.;

  • 作者单位

    Univ Freiburg Fac Biol Inst Biol 3 Genet &

    Expt Bioinformat Schanzlestr 1 D-79104 Freiburg Germany;

    Univ Freiburg Fac Biol Inst Biol 3 Genet &

    Expt Bioinformat Schanzlestr 1 D-79104 Freiburg Germany;

    Univ Turku Dept Biochem Mol Plant Biol Turku 20014 Finland;

    Univ Freiburg Fac Biol Inst Biol 3 Genet &

    Expt Bioinformat Schanzlestr 1 D-79104 Freiburg Germany;

    Saitama Univ Grad Sch Sci &

    Engn Saitama 3388570 Japan;

    Univ Turku Dept Biochem Mol Plant Biol Turku 20014 Finland;

    Univ Freiburg Fac Biol Inst Biol 3 Genet &

    Expt Bioinformat Schanzlestr 1 D-79104 Freiburg Germany;

    Univ Freiburg Fac Biol Inst Biol 3 Genet &

    Expt Bioinformat Schanzlestr 1 D-79104 Freiburg Germany;

    Univ Freiburg Fac Biol Inst Biol 3 Genet &

    Expt Bioinformat Schanzlestr 1 D-79104 Freiburg Germany;

    Univ Turku Dept Biochem Mol Plant Biol Turku 20014 Finland;

    Saitama Univ Grad Sch Sci &

    Engn Saitama 3388570 Japan;

    Univ Algarve CCMAR Ctr Marine Sci Campus Gambelas P-8005139 Faro Portugal;

    Univ Turku Dept Biochem Mol Plant Biol Turku 20014 Finland;

    Univ Freiburg Fac Biol Inst Biol 3 Genet &

    Expt Bioinformat Schanzlestr 1 D-79104 Freiburg Germany;

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  • 正文语种 eng
  • 中图分类 生物科学;
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