...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Biology: CB >Size-Dependent Expression of the Mitotic Activator Cdc25 Suggests a Mechanism of Size Control in Fission Yeast
【24h】

Size-Dependent Expression of the Mitotic Activator Cdc25 Suggests a Mechanism of Size Control in Fission Yeast

机译：有丝分裂活化剂CDC25的大小依赖性表达表明裂变酵母中尺寸控制的机制

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Proper cell size is essential for cellular function. Nonetheless, despite more than 100 years of work on the subject, the mechanisms that maintain cell-size homeostasis are largely mysterious [1]. Cells in growing populations maintain cell size within a narrow range by coordinating growth and division. Bacterial and eukaryotic cells both demonstrate homeostatic size control, which maintains population-level variation in cell size within a certain range and returns the population average to that range if it is perturbed [1, 2]. Recent work has proposed two different strategies for size control: budding yeast has been proposed to use an inhibitor-dilution strategy to regulate size at the G1/S transition [3], whereas bacteria appear to use an adder strategy, in which a fixed amount of growth each generation causes cell size to converge on a stable average [4-6]. Here we present evidence that cell size in the fission yeast Schizosaccharomyces pombe is regulated by a third strategy: the size-dependent expression of the mitotic activator Cdc25. cdc25 transcript levels are regulated such that smaller cells express less Cdc25 and larger cells express more Cdc25, creating an increasing concentration of Cdc25 as cells grow and providing a mechanism for cells to trigger cell division when they reach a threshold concentration of Cdc25. Because regulation of mitotic entry by Cdc25 is well conserved, this mechanism may provide a widespread solution to the problem of size control in eukaryotes.
机译：适当的细胞大小对于蜂窝功能至关重要。尽管如此，尽管在受试者上有超过100年的工作，但维持细胞大小稳态的机制很大程度上是神秘的[1]。在生长群体中的细胞通过协调生长和分裂维持窄范围内的细胞尺寸。细菌和真核细胞都证明了稳态尺寸控制，其在一定范围内保持细胞尺寸的人口水平变化，并且如果它被扰乱[1,2]，则将人口平均值返回到该范围内。最近的工作提出了两种不同的规模控制策略：已经提出了萌芽酵母用抑制剂稀释策略来调节G1 / S转变的尺寸[3]，而细菌似乎使用加法者策略，其中固定数量生长每代都会导致细胞大小收敛于稳定的平均值[4-6]。在这里，我们提出了裂变酵母Schizosaccharomyces Pombe中的细胞大小由第三种策略进行调节：有丝分裂活性剂CDC25的大小依赖性表达。调节CDC25转录物水平使得较小的细胞表达较少的CDC25和较大的细胞表达更多CDC25，产生CDC25的增加浓度，因为细胞在达到CDC25的阈值浓度时为细胞触发细胞划分的机制。由于CDC25的有丝分裂入口的调节良好，因此该机制可以为真核生物中的大小控制问题提供广泛的解决方案。

著录项

  • 来源
    《Current Biology: CB》 |2017年第10期|共11页
  • 作者

    Keifenheim Daniel; Sun Xi-Ming; DSouza Edridge; Ohira Makoto J.; Magner Mira; Mayhew Michael B.; Marguerat Samuel; Rhind Nicholas;

  • 作者单位

    Univ Massachusetts Med Sch Dept Biochem &

    Mol Pharmacol 364 Plantat St Worcester MA 01605 USA;

    MRC London Inst Med Sci LMS Du Cane Rd London W12 0NN England;

    Univ Massachusetts Med Sch Dept Biochem &

    Mol Pharmacol 364 Plantat St Worcester MA 01605 USA;

    Univ Massachusetts Med Sch Dept Biochem &

    Mol Pharmacol 364 Plantat St Worcester MA 01605 USA;

    Univ Massachusetts Med Sch Dept Biochem &

    Mol Pharmacol 364 Plantat St Worcester MA 01605 USA;

    Lawrence Livermore Natl Lab Computat Engn Div 7000 East Ave Livermore CA 94550 USA;

    MRC London Inst Med Sci LMS Du Cane Rd London W12 0NN England;

    Univ Massachusetts Med Sch Dept Biochem &

    Mol Pharmacol 364 Plantat St Worcester MA 01605 USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物科学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号