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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Exploring North East India's non-mulberry silk based bioinks for three dimensional bioprinting
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Exploring North East India's non-mulberry silk based bioinks for three dimensional bioprinting

机译：探索东北印度的非桑树丝绸的三维生物印刷

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摘要

Three-dimensional bioprinting has catapulted research in the domain of tissue engineering and regenerative medicine to newer heights in recent years. In this milieu, silk-based bioink has garnered tremendous research thrust. Mulberry silkworm silk fibroin has found profound impetus for formulating biocompatible and mechanically robust bioink with high-cell loading potency, used in the fabrication of 3D bio-constructs for prospective clinical applications. Pertinently, North East India's non-mulberry silk varieties 'muga' and 'eri', endowed with specific cell-binding RGD sequence, exhibit special biomaterial-attributes including better mechanical resilience than their mulberry counterparts. The recent exploitation of the former for the formulation of novel bioinks to fabricate 3D constructs for prospective meniscus, cartilage and osteochondral tissue repair merits special mention. Their self-gelling attribute permits the evasion of the use of conventional toxic chemical cross-linkers. With prospective application in the niche of regenerative medicine, these non-mulberry silk varieties seem to have seeded new anticipations vis-a-vis increasing cases of degenerative diseases and associated morbidity.
机译：近年来，三维生物监测在组织工程和再生医学领域进行了弹药研究。在这个Milieu，丝绸的Bioink已经获得了巨大的研究推力。桑蚕蚕丝丝素发现了用于配制生物相容性和机械稳健的生物芯，其具有高细胞载荷效力的生物相容性和机械稳健的生物型，用于制造3D生物构建体的前瞻性临床应用。无论如何，东北印度的非桑树丝品种'Muga'和'Eri'，赋予特定的细胞结合RGD序列，表现出特殊的生物材料属性，包括比桑树对应物更好的机械弹性。最近对前者的开发用于制定新型生物芯片，用于制作前瞻性弯月面，软骨和骨科组织修复的3D构建体验特别提及。它们的自我凝胶属性允许逃避常规有毒化学交联剂的使用。随着再生医学利基的前瞻性应用，这些非桑椹丝品种似乎已经播种了新的预期患者患者的退行性疾病和相关的发病率。

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