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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Advances in understanding of structure, function and plasticity of HCN channels
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Advances in understanding of structure, function and plasticity of HCN channels

机译：理解HCN通道结构，功能和可塑性的进步

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Hyperpolarization-activated, cyclic nucleotide-sensitive, cation non-selective (HCN) channels are gaining attention in recent years. These ion-channels are gated by two factors: voltage, specifically hyperpolarization and some subunits, more than others, by cyclic nucleotides. They conduct both sodium and potassium ions, and regulate many functions in both neuronal and non-neuronal cells. In neurons, HCN channel functions range from setting resting potential, synaptic normalization, gain control, after-hyperpolarization, setting responses in dendrites, mediating cannabinoid role in neuronal plasticity to the gating of plasticity. Emerging properties of circuits expressing HCN channels manifest in the form of various kinds of functions like brain rhythms, perception, spatial learning, executive memory, epilepsy, ataxia, depression, sound localization, anxiety, etc. We are beginning to understand the roles of these channels in non-neuronal cells and we would discover more such roles in the future. Following ischaemia, there is HCN overexpression in the reactive astrocytes. There is an altered expression of HCN channels in few tissues in diabetic animal models. Recent evidence suggests that HCN channels are also involved in uterine contractions and renal functioning. This review focuses on the function, structure, interacting proteins and developmental plasticity that enable the versatility of HCN channels.
机译：近年来，高分子化激活的循环核苷酸敏感，阳离子非选择性（HCN）通道正在关注。这些离子通道被两个因素所处为：电压，特异性超极化和一些亚基，比其他亚核苷酸多于其他亚核苷酸。它们进行钠和钾离子，并调节神经元和非神经元细胞中的许多功能。在神经元中，HCN通道功能范围从设定静息电位，突触归一化，增益控制，后超极化，树枝状内的设置响应，介导大麻素作用在神经元可塑性中与可塑性的衔接。表达HCN通道的电路的新兴属性以各种功能的形式表现为脑子节奏，感知，空间学习，执行记忆，癫痫，共济失调，抑郁，声音本土化，焦虑等。我们开始了解这些的角色非神经元细胞的频道，我们将来会发现更多这样的角色。在缺血后，活性星形胶质细胞中存在HCN过表达。在糖尿病动物模型中的几种组织中存在改变的HCN通道表达。最近的证据表明HCN通道也参与子宫收缩和肾功能。该综述侧重于使HCN通道的多功能性的功能，结构，相互作用和发育可塑性。

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