Aberration in NF kappa B-I kappa B binding may cause two states of NF kappa B activity

Singh Raghvendra

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Aberration in NF kappa B-I kappa B binding may cause two states of NF kappa B activity

机译：NF Kappa B-I Kappa B结合可能导致两种NF Kappa B活动

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NF kappa B activation is involved in cell survival and aberration of NF kappa B signalling is found in cancer. I kappa B is an inhibitor that sequesters NF kappa B in the cytoplasm. By mathematical modelling, we predict that under an aberrant condition in which I kappa B does not bind to NF kappa B, there exist two states of NF kappa B activity: a constitutive activity state for any positive value of the stimulus and a zero activity state for no stimulus. Further, under the assumption that NIK can be activated by TAB1-pTAK1, we predict that TAB1 has a role in the basal activity of NF kappa B. Thus, we predict the importance of TAB1 and I kappa B in NF kappa B activation. Our prediction may have implication for cell survival and cancer.

机译：NF Kappa B激活参与细胞存活，并且在癌症中发现了NF Kappa B信用的像差。 i Kappa B是螯合细胞质中NFκB的抑制剂。通过数学建模，我们预测，在κB的异常状况下，其中κB不与NF Kappa B结合，存在NF Kappa B活动的两种状态：刺激的任何正值的组成型活性状态和零活动状态没有刺激。此外，在假设NIK可以通过Tab1-PTAK1激活NIK，我们预测Tab1在NF Kappa B的基础活动中具有作用。因此，我们预测了TaP1和I Kappa B在NF Kappa B激活中的重要性。我们的预测可能对细胞存活和癌症有影响。

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《Current Science: A Fortnightly Journal of Research》 |2017年第11期|共7页
作者
Singh Raghvendra;
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作者单位

Indian Inst Technol Dept Chem Engn Kanpur 208016 Uttar Pradesh India;

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原文格式 PDF
正文语种 eng
中图分类自然科学现状及发展;
关键词
Basal activity; cancer; cell survival; constitutive activation; protein complex;

机译：基础活动;癌症;细胞存活;组成型激活;蛋白质复合物;

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4. Aberration in NF kappa B-I kappa B binding may cause two states of NF kappa B activity [J] . Singh Raghvendra Current Science: A Fortnightly Journal of Research . 2017,第11期

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Aberration in NF kappa B-I kappa B binding may cause two states of NF kappa B activity

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