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首页> 外文期刊>Crystal growth & design >Facile Synthesis of Luminous Nanoparticles with Tunable Size and Long-Lived Luminescence for Lifetime-Based Biosensing
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Facile Synthesis of Luminous Nanoparticles with Tunable Size and Long-Lived Luminescence for Lifetime-Based Biosensing

机译：具有可调谐尺寸的发光纳米颗粒的体积合成，基于终身的生物传感

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摘要

After the stoppage of excitation, persistent luminescence nano particles (PLNPs) can exhibit long-lived luminescence. Since the lifetime of autofluorescence is in the nanosecond range, the interference of autofluorescence can be efficiently eliminated by detecting the long-lived luminescence of PLNPs after the autofluorescence is completely attenuated. As a result, PLNPs have been widely studied in background-free bioanalysis. Despite considerable achievements have been made in the biomedical applications of PLNPs, the controlled synthesis of PLNPs is still largely undeveloped. Herein, we report the facile synthesis of Zn3Ga2GeO8:Cr (ZGGO:Cr) PLNPs with tunable size and long-lived luminescence properties by a solvothermal method. With increasing the pH value in solvothermal reaction system, the size of the prepared ZGGO:Cr PLNPs decreases gradually. Additionally, the attenuation time and intensity of persistent luminescence also decrease with the increase of the pH value. The ZGGO:Cr PLNPs were further used for lifetime-based biosensing. Core-shell structured ZGGO:Cr@MnO2 PLNPs were constructed for glutathione (GSH) detection. The concentration of GSH can be detected by simply monitoring the persistent luminescence of PLNPs after the excitation ceases. The lifetime-based ZGGO:Cr@MnO2 biosensing probe shows high selectivity and sensitivity toward GSH. The as-prepared ZGGO:Cr PLNPs feature pH-dependent size and long-lived luminescence, and have good potential in background-free biosensing and bioimaging. The reported strategy can be promoted for the controlled synthesis of other PLNPs systems and further contribute to the biomedical applications of PLNPs.
机译：在激发停止后，持续发光纳米颗粒（PLNP）可以表现出长寿命的发光。由于自发荧光的寿命在纳秒范围内，因此通过在自发荧光完全衰减之后通过检测PLNP的长寿命发光，可以有效地消除自荧光的干扰。结果，PLNP已被广泛研究在无论自由的生物分析中。尽管在PLNP的生物医学应用中取得了相当大的成果，但PLNP的受控合成仍然很大程度上未开发。在此，我们通过溶剂热法报告具有可调谐尺寸和长寿命的发光特性的Zn3Ga2GeO8：Cr（ZgGo：Cr）PLNP的容易合成。随着溶剂热反应系统中的pH值增加，制备的ZGGO的尺寸：Cr PLNP逐渐降低。另外，随着pH值的增加，持续发光的衰减时间和强度也降低。 ZGGO：Cr PLNPS进一步用于基于寿命的生物传感。核心壳结构ZGGO：Cr / MnO2 PlNP被构建用于谷胱甘肽（GSH）检测。通过简单地监测激发停止后，可以通过简单地监测PLNP的持续发光来检测GSH的浓度。基于寿命的ZGGO：Cr / MnO2生物溶解探针显示出高选择性和对GSH的敏感性。 AS制备的ZGGO：CR PLNPS具有pH依赖性大小和长寿命的发光，并具有良好的潜力在无背景生物传感和生物体。可以促进报告的策略，用于对其他PLNPS系统的对照合成，并进一步有助于PLNP的生物医学应用。

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  • 来源
    《Crystal growth & design》 |2019年第4期|共7页
  • 作者

    Hu Shushu; Li Zhiheng; Luo Qiang; Ma Qinqin; Chen Na; Fu Linna; Wang Jie; Yang Ronghua; Yuan Quan;

  • 作者单位

    Hunan Univ State Key Lab Chemo Biosensing &

    Chemometr Coll Chem &

    Chem Engn Aptamer Engn Ctr Hunan Prov Mol Sci &

    Biomed Lab MBL Inst Chem Biol &

    Nanomed Changsha 410082 Hunan Peoples R China;

    Wuhan Univ Coll Chem &

    Mol Sci Minist Educ Key Lab Analyt Chem Biol &

    Med Wuhan 430072 Hubei Peoples R China;

    Hunan Univ State Key Lab Chemo Biosensing &

    Chemometr Coll Chem &

    Chem Engn Aptamer Engn Ctr Hunan Prov Mol Sci &

    Biomed Lab MBL Inst Chem Biol &

    Nanomed Changsha 410082 Hunan Peoples R China;

    Wuhan Univ Coll Chem &

    Mol Sci Minist Educ Key Lab Analyt Chem Biol &

    Med Wuhan 430072 Hubei Peoples R China;

    Wuhan Univ Coll Chem &

    Mol Sci Minist Educ Key Lab Analyt Chem Biol &

    Med Wuhan 430072 Hubei Peoples R China;

    Hunan Univ State Key Lab Chemo Biosensing &

    Chemometr Coll Chem &

    Chem Engn Aptamer Engn Ctr Hunan Prov Mol Sci &

    Biomed Lab MBL Inst Chem Biol &

    Nanomed Changsha 410082 Hunan Peoples R China;

    Wuhan Univ Coll Chem &

    Mol Sci Minist Educ Key Lab Analyt Chem Biol &

    Med Wuhan 430072 Hubei Peoples R China;

    Changsha Univ Sci &

    Technol Sch Chem &

    Food Engn Changsha 410114 Hunan Peoples R China;

    Hunan Univ State Key Lab Chemo Biosensing &

    Chemometr Coll Chem &

    Chem Engn Aptamer Engn Ctr Hunan Prov Mol Sci &

    Biomed Lab MBL Inst Chem Biol &

    Nanomed Changsha 410082 Hunan Peoples R China;

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  • 正文语种 eng
  • 中图分类 晶体学;
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