Mesoporous Metal-Organic Frameworks as Effective Nucleating Agents in Protein Crystallography

Leite Jose P.; Rodrigues Diogo; Ferreira Susana; Figueira Flavio; Almeida Paz Filipe A.; Gales Luis

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Mesoporous Metal-Organic Frameworks as Effective Nucleating Agents in Protein Crystallography

机译：中孔金属 - 有机框架作为蛋白质结晶中的有效成核剂

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Mesoporous metal-organic frameworks (mesoMOFs) have gained some attention as protein immobilization agents. Herein, and for the first time, three model proteins (lysozyme, trypsin, and albumin) were used to show that crystallization is effectively induced when the protein is immobilized inside the mesoMOF, with this occurring for lysozyme, while trypsin and albumin were size-excluded. It is shown that heterogeneous nucleation is truly remarkable in the case of lysozyme with a strong adhesion to the mesoMOF surface. These findings suggest that the ability to fix the target protein with a molecular-scale periodicity constitutes a significant advantage of mesoMOFs over other nucleating agents.

机译：中孔金属 - 有机框架（Mesomofs）作为蛋白质固定剂的注意力。在此，使用三种模型蛋白质（溶菌酶，胰蛋白酶和白蛋白）表明当蛋白质在中间蛋白质内固定在中间蛋白质内时，有效地诱导结晶，用这发生溶菌酶，而胰蛋白酶和白蛋白是尺寸的被排除在外。结果表明，在溶菌酶的情况下，异质成核在具有强烈粘附到中间蛋白酶表面的情况下真正显着。这些发现表明，用分子尺度周期固定靶蛋白的能力构成了Mesomofs对其他成核剂的显着优势。

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来源
《Crystal growth & design》 |2019年第3期|共6页
作者
Leite Jose P.; Rodrigues Diogo; Ferreira Susana; Figueira Flavio; Almeida Paz Filipe A.; Gales Luis;
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Inst Invest &

Inovacao Saude Rua Alfredo Allen 208 Porto Portugal;

Inst Invest &

Inovacao Saude Rua Alfredo Allen 208 Porto Portugal;

Inst Invest &

Inovacao Saude Rua Alfredo Allen 208 Porto Portugal;

Univ Aveiro Dept Chem CICECO Aveiro Inst Mat Campus Univ Santiago Aveiro Portugal;

Univ Aveiro Dept Chem CICECO Aveiro Inst Mat Campus Univ Santiago Aveiro Portugal;

Inst Invest &

Inovacao Saude Rua Alfredo Allen 208 Porto Portugal;

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正文语种 eng
中图分类晶体学;
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1. Mesoporous Metal-Organic Frameworks as Effective Nucleating Agents in Protein Crystallography [J] . Leite Jose P., Rodrigues Diogo, Ferreira Susana, Crystal growth & design . 2019,第3期

机译：中孔金属 - 有机框架作为蛋白质结晶中的有效成核剂
2. Synthesis of magnetic mesoporous metal-organic framework-5 for the effective enrichment of malachite green and crystal violet in fish samples [J] . Zhou Zhihui, Fu Yanqing, Qin Qian, Journal of chromatography, A: Including electrophoresis and other separation methods . 2018,第期

机译：磁性介孔金属 - 有机框架-5的合成，用于在鱼类样品中有效富集孔雀石绿和水晶紫中的富集
3. Effective and Selective Catalysts for Cinnamaldehyde Hydrogenation: Hydrophobic Hybrids of Metal-Organic Frameworks, Metal Nanoparticles, and Micro- and Mesoporous Polymers [J] . Yuan Kuo, Song Tianqun, Wang Dawei, Angewandte Chemie . 2018,第20期

机译：用于肉桂醛氢化的有效和选择性催化剂：金属 - 有机骨架，金属纳米颗粒和微孔和中间孔聚合物的疏水杂种
4. (Keynote) Biomimetic Preservation of Protein and Cell Surface Markers with Metal-Organic Frameworks for Controlled Protein Delivery and Room Temperature Storage and Shipping [C] . Jeremiah J Gassensmith Pacific Rim Meeting on Electrochemical and Solid-State Science . 2020

机译：（Keynote）用金属 - 有机框架进行蛋白质和细胞表面标志物的仿真保存，用于受控蛋白质输送和室温储存和运输
5. Computational Modeling of Metal-Organic Frameworks for the Catalytic Hydrolysis of Nerve Agents and Their Simulants [D] . Mendonca, Matthew L. 2020

机译：金属有机框架的计算模拟神经剂催化水解及其模拟剂
6. Hierarchical Structure with Highly Ordered Macroporous-Mesoporous Metal-Organic Frameworks as Dual Function for CO2 Fixation [O] . Zhenxing Li, Xiaofei Xing, Dong Meng, 2019

机译：具有高序大孔-中孔金属-有机骨架的双层结构具有固定二氧化碳的双重功能
7. Cover Feature: Unveiling the Binding Modes of the Crystallophore, a Terbium-based Nucleating and Phasing Molecular Agent for Protein Crystallography (Chem. Eur. J. 39/2018) [O] . Sylvain Engilberge, François Riobé, Tristan Wagner, 2018

机译：盖子特征：揭示结晶的结合模式，蛋白质晶体学（Chem.Eur.J.39 / 2018）的基于铽基成核和阶段分子剂。

Mesoporous Metal-Organic Frameworks as Effective Nucleating Agents in Protein Crystallography

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