...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Crystal growth & design >Revealing the Nanostructure of Glyceryl Tristearate Crystals by Atomic Force Microscopy
【24h】

Revealing the Nanostructure of Glyceryl Tristearate Crystals by Atomic Force Microscopy

机译：通过原子力显微镜揭示甘油三分晶晶体的纳米结构

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Habit and morphology of triglyceride crystals are critical factors in the formulation of lipid-based colloidal systems such as pharmaceutical formulations and dairy products. Until now, triglyceride crystal characterization has been largely performed using thermal analysis, scattering techniques, and electron microscopy. We present the use of Atomic Force Microscopy (AFM) for the 3-dimensional mapping of the nanoscale morphology of single glyceryl tristearate (tristearin) crystals. We show in great detail the topographical features of tristearin crystals not apparent using other techniques, and investigate the effect of solvent-mediated recrystallization on crystal morphology. Specifically, recrystallization from toluene results in the production of well-ordered crystals with a regular lamellar thickness of 5 nm, and a habit that depends on the rate of evaporation. X-ray diffraction (XRD) analysis confirms that the crystalline phase prior to and following recrystallization is maintained; however, the bulky lamellar structure is replaced with a thin, ordered structure. The use of AFM circumvents the disadvantages of electron microscopy, such as melting of triglyceride crystals and freezing of aqueous phase residue. The approach presented in this work gives new physical insight into the 3-dimensional features of the crystals, which will have an influence of their behavior in lipid-based soft matter and colloidal systems.
机译：甘油三酯晶体的习性和形态是在药物制剂和乳制品等脂质的胶体系统配制中的关键因素。到目前为止，甘油三酯晶体表征在很大程度上使用了热分析，散射技术和电子显微镜进行。我们介绍了原子力显微镜（AFM）对单糖型晶体（Tristearin）晶体的纳米级形态的三维映射。我们详细展示了使用其他技术的Tristearin晶体的地形特征，并研究溶剂介导的重结晶对晶体形态的影响。具体地，从甲苯中重结晶导致生产具有常规层状厚度为5nm的良好有序的晶体，以及取决于蒸发速率的习惯。 X射线衍射（XRD）分析证实，保持了重结晶前和后续的结晶相;然而，庞大的层状结构被薄，有序的结构代替。使用AFM旨在避免电子显微镜的缺点，例如甘油三酯晶体的熔化和水相残余物的冷冻。本作作品中呈现的方法为晶体的三维特征提供了新的身体洞察，这将对其在基于脂质的柔软物质和胶体系统中的行为产生影响。

著录项

  • 来源
    《Crystal growth & design》 |2019年第1期|共7页
  • 作者

    Gao Nan; Sebben Damien A.; Gillies Graeme; Krasowska Marta; Beattie David A.;

  • 作者单位

    Univ South Australia Future Ind Inst Mawson Lakes Campus Mawson Lakes SA 5095 Australia;

    Univ South Australia Future Ind Inst Mawson Lakes Campus Mawson Lakes SA 5095 Australia;

    Fonterra Res &

    Dev Ctr Dairy Farm Rd Palmerston North 4472 New Zealand;

    Univ South Australia Future Ind Inst Mawson Lakes Campus Mawson Lakes SA 5095 Australia;

    Univ South Australia Future Ind Inst Mawson Lakes Campus Mawson Lakes SA 5095 Australia;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 晶体学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号