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首页> 外文期刊>Crystal growth & design >Influence of Fluid Motions on Polymorphic Crystallization of l-Histidine: Taylor Vortex Flow and Turbulent Eddy Flow
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Influence of Fluid Motions on Polymorphic Crystallization of l-Histidine: Taylor Vortex Flow and Turbulent Eddy Flow

机译：流体运动对L-组氨酸多态性结晶的影响：Taylor Vortex流动和湍流涡流

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摘要

The mechanistic influence of fluid motions, such as a Taylor vortex flow and turbulent eddy flow, on the polymorphic crystallization of l-histidine was investigated. Couette–Taylor (CT) and mixing tank (MT) crystallizers were used for the Taylor vortex flow and turbulent eddy flow, respectively. Due to its periodic fluid motion, the Taylor vortex flow was found to be more favorable than the turbulent eddy flow for polymorphic nucleation of the stable phase. Thus, the polymorphic fraction of the stable phase at the induction point (called the “initial stable polymorphic fraction”) in the CT crystallizer was always much higher than that in the MT crystallizer for all variations of the crystallization conditions, including the rotation/agitation speed, ethanol fraction in the mixture solvent, and cooling rate. When increasing the rotation speed of the inner cylinder in the CT crystallizer, the initial stable polymorphic fraction was significantly increased and reached 100% at a rotation speed above 700 rpm. A 100% initial stable polymorphic nucleation was not achievable in the MT crystallizer, even at a high agitation speed over 2500 rpm. The periodic Taylor vortex was also effective for mass transfer. Thus, the phase transformation rate in the CT crystallizer was several scores higher than that in the MT crystallizer. The polymorphic crystallization with the two fluid motions when varying the rotation/agitation speed, ethanol fraction in the mixture solvent, and cooling rate was also described using a simple model based on flow-induced nucleation and mass transfer. The model successfully predicted the experimental results of the initial stable polymorphic fraction and phase transformation rate in both crystallizers with all variations of the crystallization conditions. According to the model, the periodic fluid motion of the Taylor vortex flow was much more effective than the turbulent eddy flow for promoting stable polymorphic nucleation and phase transformation.
机译：研究了流体运动的机械影响，例如泰勒涡流流动和湍流涡流，对L-组氨酸多态性结晶的影响。 Coute-Taylor（CT）和混合罐（MT）结晶剂分别用于泰勒涡流流动和湍流涡流。由于其周期性流体运动，发现泰勒涡流比稳定相的多态性成核的湍流涡流更有利。因此，CT结晶器中诱导点（称为“初始稳定多晶级分数”）的稳定相的多态分数总是远高于MT结晶器中的所有变化，包括旋转/搅拌速度，乙醇馏分在混合溶剂和冷却速率。当增加CT结晶器中内圆筒的转速时，初始稳定的多晶型级分显着增加，以高于700rpm的旋转速度达到100％。在MT结晶器中，甚至在2500rpm超过2500rpm的高搅拌速度下，Mt结晶器中不可能实现100％初始稳定的多态性成核。周期性泰勒涡旋也有效地对传质。因此，CT结晶器中的相变率高于MT结晶器中的几分比。使用简单的模型，使用基于流动诱导的成核和传质，对混合物溶剂中的乙醇分数和冷却速率进行了两种流体运动的多态结晶。该模型成功地预测了在结晶条件的所有变化中的结晶剂中初始稳定多态性级分和相变速率的实验结果。根据该模型，泰勒涡流的周期性流体运动比用于促进稳定多态性成核和相变的湍流涡流更有效。

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  • 来源
    《Crystal growth & design》 |2018年第2期|共13页
  • 作者

    Suna Park; Woo-Sik Kim;

  • 作者单位

    Department of Chemical Engineering Kyung Hee University Kyungki-do 449-701 Korea;

    Department of Chemical Engineering Kyung Hee University Kyungki-do 449-701 Korea;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 晶体学;
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