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首页> 外文期刊>Crystal growth & design >Rational Coformer Selection and the Development of New Crystalline Multicomponent Forms of Resveratrol with Enhanced Water Solubility
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Rational Coformer Selection and the Development of New Crystalline Multicomponent Forms of Resveratrol with Enhanced Water Solubility

机译：具有增强的水溶解度的合理联合体选择和新型结晶多组分形式的白藜芦醇

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摘要

We report the development of 10 new cocrystal forms of the nutraceutical compound resveratrol obtained through a rational coformer screening by utilizing the interaction site pairing energy differences computed based on molecular electrostatic potential calculations. A new monohydrate form of resveratrol and 10 novel cocrystals with 9 different coformers were characterized in the study. Among the newly developed solid forms of resveratrol, two of its cocrystals with (1) a Generally Recognized As Safe compound piperazine and (2) the bioactive compound methenamine were subjected to aqueous solubility determination. The newly developed piperazine cocrystal exhibits the highest aqueous solubility among the previously known cocrystals of resveratrol.
机译：通过利用基于分子静电潜在计算计算的相互作用位点配对能量差异，我们报告了通过合理的CoFormer筛选获得的营养素化合物白藜芦醇的10种新的CoCrystal形式。 在研究中，将一种新的一水合物形式的白藜芦醇和10种新的酰胺，其研究表征了9种不同的连凝剂。 在新开发的固体形式的白藜芦醇中，其中两种聚晶与（1）普遍认为是安全化合物哌嗪和（2）对生物活性化合物甲胺进行水溶性测定。 新开发的哌嗪烯库在先前已知的白藜芦醇中的含水溶解度上表现出最高的水溶性。

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  • 来源
    《Crystal growth & design》 |2018年第3期|共12页
  • 作者

    BasantKumar Mehta; Shiv Shankar Singh; Swati Chaturvedi; Muhammad Wahajuddin; Tejender S. Thakur;

  • 作者单位

    Molecular and Structural Biology Division and Pharmacokinetics and Metabolism Division CSIR-Central Drug Research Institute Lucknow 226 031 India;

    Molecular and Structural Biology Division and Pharmacokinetics and Metabolism Division CSIR-Central Drug Research Institute Lucknow 226 031 India;

    Molecular and Structural Biology Division and Pharmacokinetics and Metabolism Division CSIR-Central Drug Research Institute Lucknow 226 031 India;

    Molecular and Structural Biology Division and Pharmacokinetics and Metabolism Division CSIR-Central Drug Research Institute Lucknow 226 031 India;

    Molecular and Structural Biology Division and Pharmacokinetics and Metabolism Division CSIR-Central Drug Research Institute Lucknow 226 031 India;

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  • 正文语种 eng
  • 中图分类 晶体学;
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