Protective Effects of Quercetin against Pyrazinamide Induced Hepatotoxicity via a Cocrystallization Strategy of Complementary Advantages

Liu Fang; Wang Ling-Yang; Li Yan-Tuan; Wu Zhi-Yong; Yan Cui-Wei

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Protective Effects of Quercetin against Pyrazinamide Induced Hepatotoxicity via a Cocrystallization Strategy of Complementary Advantages

机译：槲皮素对吡嗪酰胺诱导肝毒性互补策略互补优势的保护作用

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Reducing effectively toxic side effects is a challenging subject in drug development. The reported herein cocrystallization of pyrazinamide with quercetin has complementary advantages, enhancing the in vitro/vivo performance of quercetin and taming the pharmacokinetic synergy of quercetin and pyrazinamide, almost removing pyrazinamide induced hepatotoxicity. The findings stimulate the application of active pharmaceutical ingredient-nutraceutical cocrystallization to solve the toxicity issue of drugs.

机译：减少有效的毒性副作用是药物发育中有挑战性的主题。本文报道的吡嗪酰胺与槲皮素的共聚化具有互补优点，增强了槲皮素的体外/体内性能，并驯服了槲皮素和吡嗪酰胺的药代动力学协同作用，几乎除去了吡嗪酰胺诱导的肝毒性。该研究结果刺激了活性药物成分 - 营养保健金属化合物化以解决药物的毒性问题。

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《Crystal growth & design》 |2018年第7期|共5页
作者
Liu Fang; Wang Ling-Yang; Li Yan-Tuan; Wu Zhi-Yong; Yan Cui-Wei;
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作者单位

Ocean Univ China Sch Med &

Pharm Qingdao 266003 Peoples R China;

Ocean Univ China Sch Med &

Pharm Qingdao 266003 Peoples R China;

Ocean Univ China Sch Med &

Pharm Qingdao 266003 Peoples R China;

Ocean Univ China Sch Med &

Pharm Qingdao 266003 Peoples R China;

Ocean Univ China Coll Marine Life Sci Qingdao 266003 Peoples R China;

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正文语种 eng
中图分类晶体学;
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1. Protective Effects of Quercetin against Pyrazinamide Induced Hepatotoxicity via a Cocrystallization Strategy of Complementary Advantages [J] . Liu Fang, Wang Ling-Yang, Li Yan-Tuan, Crystal growth & design . 2018,第7期

机译：槲皮素对吡嗪酰胺诱导肝毒性互补策略互补优势的保护作用
2. Protective effects of a combination of quercetin and vitamin E against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. [J] . Mostafavi-Pour Z, Zal F, Monabati A, Hepatology research: the official journal of the Japan Society of Hepatology . 2008,第4期

机译：槲皮素和维生素E的组合对大鼠环孢素A诱导的氧化应激和肝毒性的保护作用。
3. Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents. [J] . Janbaz KH, Saeed SA, Gilani AH Phytomedicine : . 2004,第5期

机译：咖啡酸和槲皮素对啮齿动物化学性肝毒性的保护作用研究。
4. Protective effects of thymosin β4 on carbon tetrachloride-induced acute hepatotoxicity in rats [C] . Karina Reyes-Gordillo, Ruchi Shah, Jaime Arellanes-Robledo, International Symposium on Thymosins in Health and Disease . 2012

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5. Protective strategies against acetaminophen induced hepatotoxicity [D] . Saito, Chieko 2010

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6. The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats [O] . Mohamed Anwar K Abdelhalim, Sherif A Abdelmottaleb Moussa, Huda Abdo Yahya Qaid 2018

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7. Potential protective effects of Quercetin on metalaxyl-induced oxidative stress, impaired liver functions and hepatotoxicity in rat [O] . Samy Hussein, Yakout El Senosi, Mogda Mansour, 2017

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Protective Effects of Quercetin against Pyrazinamide Induced Hepatotoxicity via a Cocrystallization Strategy of Complementary Advantages

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