Tracking Crystallophore Nucleating Properties: Setting Up a Database for Statistical Analysis

Jiang Tao; Roux Amandine; Engilberge Sylvain; Alsalman Zaynab; Di Pietro Sebastiano; Franzetti Bruno; Riobe Francois; Maury Olivier; Girard Eric

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Tracking Crystallophore Nucleating Properties: Setting Up a Database for Statistical Analysis

机译：跟踪Crystallophore成核特性：设置数据库以进行统计分析

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In this article, the principle of a database aimed at facilitating the understanding of the unique protein nucleating properties of the crystallophore is presented. A first analysis allows us to compare the efficiency of Tb-Xo4 with the new Lu-Xo4 variant, featuring improved phasing properties. Then, the concept of subset-of-interest is introduced to reveal potential antagonistic/synergistic effects between Tb-Xo4 and physicochemical parameters of the crystallization kits such as pH. The overall approach may be of interest for any studies working on solutions dedicated to improve the nucleating step in protein crystallization.

机译：在本文中，介绍了旨在促进理解结晶的独特蛋白质成核特性的数据库的原理。第一个分析允许我们将TB-XO4的效率与新的LU-XO4变体进行比较，具有改进的相位性能。然后，引入了兴趣次级概念的概念，以揭示TB-XO4与诸如pH的结晶试剂盒的物理化学参数之间的潜在拮抗/协同效应。对于致力于改善蛋白质结晶中的成核步骤的解决方案的任何研究，整体方法可能是有意义的。

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《Crystal growth & design》 |2020年第8期|共8页
作者
Jiang Tao; Roux Amandine; Engilberge Sylvain; Alsalman Zaynab; Di Pietro Sebastiano; Franzetti Bruno; Riobe Francois; Maury Olivier; Girard Eric;
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作者单位

Univ Claude Bernard Lyon 1 Univ Lyon ENS Lyon CNRS UMR 5182 Lab Chim F-69342 Lyon France;

Univ Claude Bernard Lyon 1 Univ Lyon ENS Lyon CNRS UMR 5182 Lab Chim F-69342 Lyon France;

Univ Grenoble Alpes CEA CNRS Inst Biol Struct F-38000 Grenoble France;

Univ Grenoble Alpes CEA CNRS Inst Biol Struct F-38000 Grenoble France;

Univ Claude Bernard Lyon 1 Univ Lyon ENS Lyon CNRS UMR 5182 Lab Chim F-69342 Lyon France;

Univ Grenoble Alpes CEA CNRS Inst Biol Struct F-38000 Grenoble France;

Univ Claude Bernard Lyon 1 Univ Lyon ENS Lyon CNRS UMR 5182 Lab Chim F-69342 Lyon France;

Univ Claude Bernard Lyon 1 Univ Lyon ENS Lyon CNRS UMR 5182 Lab Chim F-69342 Lyon France;

Univ Grenoble Alpes CEA CNRS Inst Biol Struct F-38000 Grenoble France;

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正文语种 eng
中图分类晶体学;
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1. Tracking Crystallophore Nucleating Properties: Setting Up a Database for Statistical Analysis [J] . Jiang Tao, Roux Amandine, Engilberge Sylvain, Crystal growth & design . 2020,第8期

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7. Tracking crystallophore nucleating properties: setting-up a database for statistical analysis [O] . Tao Jiang, Amandine Roux, Sylvain Engilberge, 2020

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Tracking Crystallophore Nucleating Properties: Setting Up a Database for Statistical Analysis

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