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首页> 外文期刊>Crystal growth & design >Direct Processing of a Flow Reaction Mixture Using Continuous Mixed Suspension Mixed Product Removal Crystallizer
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Direct Processing of a Flow Reaction Mixture Using Continuous Mixed Suspension Mixed Product Removal Crystallizer

机译：使用连续混合悬浮混合产物去除结晶器直接加工流动反应混合物

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摘要

Crystallization as the most widespread purification, separation, and morphology-determining method is a critical technology that could be made safer and more economical by using continuous crystallization alternatives. Accordingly, this study aims to develop the continuous crystallization method for direct processing of a flow reaction mixture of acetylsalicylic acid (ASA) and to provide pure, homogeneous crystalline products for further formulation steps. The solid-liquid separation and the purification of the acetylsalicylic acid from the multicomponent mixture were accomplished in a single stage mixed suspension mixed product removal (MSMPR) continuous crystallizer equipped with an overflow and an inner buffer element to ensure the representative withdrawal of the product suspension. The effect of process parameters such as the operating temperature and the length of residence time (RT) on product quality and quantity were studied at two and three levels, respectively. Investigating these parameters, we found that higher operating temperatures (25 degrees C) and longer residence time (47 min) favor appropriate purity (>99.5%), and narrow crystal size distribution. By reducing the operating temperature (2.5 degrees C), the yield improved slightly (approximately 77%) and polydisperse products were characterized. The developed crystallization process can link the flow synthesis with the continuous formulation, and consequently serves a further step toward end-to-end production.
机译：结晶作为最广泛的纯化，分离和形态学确定方法是一种关键技术，可以通过使用连续结晶替代品来使得更安全和更经济。因此，本研究旨在开发用于直接加工乙酰山醛酸（ASA）的流动反应混合物的连续结晶方法，并提供纯，均匀的结晶产物，用于进一步配制步骤。在配备有溢流和内缓冲元件的单级混合悬浮混合产物去除（MSMPR）连续结晶器中，完成从多组分混合物的固液分离和乙酰胱氨酸纯化。以确保产品悬浮液的代表性撤回。在两个和三个层面分别研究了工艺参数如操作温度和停留时间（RT）的影响，分别研究了产品质量和数量。研究这些参数，我们发现更高的工作温度（25摄氏度）和较长的停留时间（47分钟）赞成适当的纯度（> 99.5％）和窄晶体尺寸分布。通过减小工作温度（2.5℃），表征略微略微改善产率（约77％）和多分散产品。开发的结晶过程可以将流量合成与连续制剂连接，因此朝向端到端生产的进一步阶跃。

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  • 来源
    《Crystal growth & design》 |2020年第7期|共10页
  • 作者

    Tacsi Kornelia; Pataki Hajnalka; Domokos Andras; Nagy Brigitta; Csontos Istvan; Markovits Imre; Farkas Ferenc; Nagy Zsombor Kristof; Marosi Gyorgy;

  • 作者单位

    Tech Univ Budapest Dept Organ Chem &

    Technol H-1111 Budapest Hungary;

    Tech Univ Budapest Dept Organ Chem &

    Technol H-1111 Budapest Hungary;

    Tech Univ Budapest Dept Organ Chem &

    Technol H-1111 Budapest Hungary;

    Tech Univ Budapest Dept Organ Chem &

    Technol H-1111 Budapest Hungary;

    Tech Univ Budapest Dept Organ Chem &

    Technol H-1111 Budapest Hungary;

    Egis Pharmaceut PLC Drug Subst Dev Div Drug Subst Pilot Plant Directorate Drug Subst Dev H-1106 Budapest Hungary;

    Egis Pharmaceut PLC Drug Subst Dev Div Drug Subst Pilot Plant Directorate Drug Subst Dev H-1106 Budapest Hungary;

    Tech Univ Budapest Dept Organ Chem &

    Technol H-1111 Budapest Hungary;

    Tech Univ Budapest Dept Organ Chem &

    Technol H-1111 Budapest Hungary;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 晶体学;
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