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首页> 外文期刊>Crystal growth & design >Effect of Polymer Molecular Weight on the Crystallization Behavior of Indomethacin Amorphous Solid Dispersions
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Effect of Polymer Molecular Weight on the Crystallization Behavior of Indomethacin Amorphous Solid Dispersions

机译：聚合物分子量对吲哚美甲酰胺无定形固体分散体结晶行为的影响

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摘要

The influence of the molecular weight of polyvinylpyrrolidone (PVP) on the molecular mobility and physical stability of indomethacin (IMC)-PVP solid dispersions was investigated over a wide temperature range in the supercooled state. As the polymer molecular weight increased, there was a decrease in molecular mobility as evident from the longer a-relaxation times. Inhibition of IMC crystallization also increased as a function of polymer molecular weight. The extent of H-bonding interaction between drug and polymer, quantified by ssNMR, was independent of polymer molecular weight. Over a polymer concentration range of 5-20% w/w, the temperature dependence of mobility and viscosity was reasonably similar for different grades of PVP. It was concluded that the increase in effectiveness in crystallization inhibition as a function of polymer molecular weight is due to the increased viscosity, which slows down the mobility of these systems.
机译：聚乙烯基吡咯烷酮（PVP）分子量对吲哚美辛（IMC）-PVP固体分散体的分子迁移率和物理稳定性的影响在过冷状态的宽温度范围内研究。 随着聚合物分子量的增加，从较长的弛豫时间开始，分子迁移率降低。 作为聚合物分子量的函数，IMC结晶的抑制也增加。 通过SSNMR定量的药物和聚合物之间的H键合相互作用的程度与聚合物分子量无关。 在5-20％w / w的聚合物浓度范围内，对于不同等级的PVP，迁移率和粘度的温度依赖性相似。 得出结论：作为聚合物分子量的函数的结晶抑制有效增加是由于粘度增加，这减缓了这些系统的迁移率。

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