Molecular Salts of L-Carnosine: Combining a Natural Antioxidant and Geroprotector with 'Generally Regarded as Safe' (GRAS) Organic Acids

Shemchuk Oleksii; Andre Vania; Duarte M. Teresa; Taddei Paola; Rubini Katia; Braga Dario; Grepioni Fabrizia

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Molecular Salts of L-Carnosine: Combining a Natural Antioxidant and Geroprotector with 'Generally Regarded as Safe' (GRAS) Organic Acids

机译：L-肉苷的分子盐：将天然抗氧化剂和Geropotector与“通常被认为是安全”（GRAS）有机酸组合

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The potent natural hydrophilic antioxidant L-carnosine has been reacted with a number of organic acids belonging to the "generally regarded as safe" (GRAS) group, resulting in the preparation of 11 new crystalline salts, which were characterized by X-ray powder diffraction and thermal analysis; the structures of six of them were determined from powder data, and one was fully characterized via single crystal data. The reaction with folic acid resulted in an amorphous folate salt, which was characterized by a combination of thermal methods and Raman spectroscopy; the solubility of the folate salt was also measured and found to be comparable to that of the commercial sodium folate.

机译：有效的天然亲水性抗氧化液L-碳苷与属于“通常被认为是安全”（GRAS）组的多种有机酸反应，导致制备11种新的结晶盐，其特征在于X射线粉末衍射和热分析; 其中六个的结构是由粉末数据确定的，并且通过单晶数据完全表征。与叶酸的反应导致无定形叶酸盐，其特征在于热方法和拉曼光谱的组合; 还测量叶酸盐的溶解度，发现与商业叶酸的溶解度相当。

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《Crystal growth & design》 |2017年第6期|共8页
作者
Shemchuk Oleksii; Andre Vania; Duarte M. Teresa; Taddei Paola; Rubini Katia; Braga Dario; Grepioni Fabrizia;
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作者单位

Univ Bologna Dipartimento Chim G Ciamician Via Selmi 2 I-40126 Bologna Italy;

Univ Lisbon Inst Super Tecn Ctr Quim Estrutural Av Rovisco Pais P-1049001 Lisbon Portugal;

Univ Lisbon Inst Super Tecn Ctr Quim Estrutural Av Rovisco Pais P-1049001 Lisbon Portugal;

Univ Bologna Dipartimento Sci Biomed &

Neuromotorie Via Belmeloro 8-2 I-40126 Bologna Italy;

Univ Bologna Dipartimento Chim G Ciamician Via Selmi 2 I-40126 Bologna Italy;

Univ Bologna Dipartimento Chim G Ciamician Via Selmi 2 I-40126 Bologna Italy;

Univ Bologna Dipartimento Chim G Ciamician Via Selmi 2 I-40126 Bologna Italy;

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正文语种 eng
中图分类晶体学;
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1. Molecular Salts of L-Carnosine: Combining a Natural Antioxidant and Geroprotector with "Generally Regarded as Safe" (GRAS) Organic Acids [J] . Shemchuk Oleksii, Andre Vania, Duarte M. Teresa, Crystal growth & design . 2017,第6期

机译：L-肉苷的分子盐：将天然抗氧化剂和Geropotector与“通常被认为是安全”（GRAS）有机酸组合
2. Resistance evaluation biological controller yeast to substances "GRAS" - (Generally Regarded As Safe) / Avalia??o da resistência de leveduras biocontroladoras à substancias “GRAS” - (Generally Regarded As Safe) [J] . Eskálath Morganna Silva Ferreira, Camilla Martins Malta, Leisciany Vieira Gonzaga, Journal of Bioenergy and Food Science . 2015,第2015期

机译：评估生物防治酵母菌对“ GRAS”物质的抵抗力-（通常被认为是安全的）/评估生物防治酵母菌对“ GRAS”物质的抵抗力-（通常被认为是安全的）
3. Carnosine as a natural antioxidant and geroprotector: from molecular mechanisms to clinical trials. [J] . Boldyrev AA, Stvolinsky SL, Fedorova TN, Rejuvenation research . 2010,第2a3期

机译：肌肽是一种天然的抗氧化剂和代糖保护剂：从分子机理到临床试验。
4. REMOVAL OF SALT AND ORGANIC ACIDS FROM SOLUTION USED TO SEASON SALTED JAPANESE APRICOTS (UME) BY COMBINING ELECTRODIALYSIS AND ADSORPTION [C] . W. TAKATSUJI, H. YOSHIDA Pacific Basin Conference on Adsorption Science and Technology . 2003

机译：通过组合电渗析和吸附来除去用于溶液的溶液中盐和有机酸
5. Microbial Safety, Shelf Life Stability, Quality Preservation, and Consumer Acceptance of Vacuum-infused, Irradiated Chicken BreastMeat Treated with Natural Plant Extracts and Organic Acids. [D] . Over, Kenneth F. 2015

机译：天然植物提取物和有机酸处理的真空注入辐照鸡胸肉的微生物安全性，保质期稳定性，质量保留和消费者接受度。
6. L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. [O] . M A Babizhayev, M C Seguin, J Gueyne, 1994

机译：L-肌肽（β-丙氨酰-L-组氨酸）和carcinine（β-丙氨酰组胺）是天然的抗氧化剂具有清除自由基和脂质过氧化物酶的活性。
7. Optimizing physicochemical properties of naturalantioxidants and geroprotectors: L-carnosine and melatonin [O] . Shemchuk Oleksii 2015

机译：优化天然抗氧化剂和代糖保护剂的理化特性：左旋肌肽和褪黑激素

Molecular Salts of L-Carnosine: Combining a Natural Antioxidant and Geroprotector with 'Generally Regarded as Safe' (GRAS) Organic Acids

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