...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Crystal growth & design >Continuous Production of Spherical Multicrystals by Extractive Crystallization in a Droplet Based Fluidic Device
【24h】

Continuous Production of Spherical Multicrystals by Extractive Crystallization in a Droplet Based Fluidic Device

机译：通过在液滴流体装置中萃取结晶，连续生产球形多晶体

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A novel continuous fluidic method based on extractive crystallization for producing monodisperse spherical crystal aggregates with potential use in pharmaceutical engineering is presented. A model system of aqueous solution containing KCl as the precursor dispersed phase and 1-hexanol as the continuous extraction phase was investigated experimentally. Monodisperse droplets of the aqueous phase were generated by a fluidic T-junction in the stable dripping regime. Supersaturation was achieved by extraction of the aqueous phase into the organic phase. The effect of extraction rate on the size, morphology, and internal pore structure of the resulting spherical crystal aggregates was systematically investigated. It was shown that nearly monodisperse particles with a tunable size can be produced by adjusting the initial solute concentration. The dissolution rates of the resulting spherical aggregates were measured and compared with single cubic crystals of identical mass. It was shown that a four- to five-fold improvement in the dissolution rate constant can be obtained due to the internal porosity of the multicrystals, compared to single cubic crystals of identical size.
机译：提出了一种基于用于产生具有药物工程潜在用途的单分散球形晶体聚集体的新型连续流体方法。实验研究了含有KCl作为前体分散相和1-六醇作为连续提取相的水溶液的模型系统。水相的单分散液滴由稳定的滴水状态下的流体T接合产生。通过将水相提取到有机相中来实现过饱和。系统研究了提取率对所得球形晶体聚集体的尺寸，形态和内部孔结构的影响。结果表明，通过调节初始溶质浓度，可以产生具有可调谐尺寸的几乎单分散颗粒。测量所得球形聚集体的溶出速率并与单立方晶体相比的相同质量进行比较。结果表明，与多晶体的内部孔隙率相比，可以获得溶解速率常数的四到五倍的改善，与相同尺寸的单个立方晶体相比。

著录项

  • 来源
    《Crystal growth & design》 |2017年第7期|共7页
  • 作者

    Kalny Martin; Pittermannova Anna; Zadrazil Ales; Stepanek Frantisek;

  • 作者单位

    Univ Chem &

    Technol Prague Dept Chem Engn Tech 5 Prague 16628 6 Czech Republic;

    Univ Chem &

    Technol Prague Dept Chem Engn Tech 5 Prague 16628 6 Czech Republic;

    Univ Chem &

    Technol Prague Dept Chem Engn Tech 5 Prague 16628 6 Czech Republic;

    Univ Chem &

    Technol Prague Dept Chem Engn Tech 5 Prague 16628 6 Czech Republic;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 晶体学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号