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首页> 外文期刊>Crystal growth & design >Elucidating the Effects of Polyprotic Acid Speciation in Calcium Oxalate Crystallization
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Elucidating the Effects of Polyprotic Acid Speciation in Calcium Oxalate Crystallization

机译：阐明多胶酸形态在草酸钙结晶中的作用

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摘要

Polyprotic acids tend to be very effective modifiers of crystals in synthetic, natural, and biological systems. Examples include calcium biomineralization where proteins and organic acids decorated with carboxylic acids act as inhibitors of crystal growth. For crystals implicated in pathological diseases, large variations in the pH of the growth medium can alter the speciation of polyprotic acids. This is particularly true for calcium minerals comprised of polyprotic counterions wherein changes in solute speciation affect supersaturation, and thus the kinetics of crystal growth. Here, we explore the combined effects of solute and modifier speciation, selecting calcium oxalate monohydrate (COM) as a representative system for calcification. COM is a major constituent of human kidney stones where crystallization in vivo occurs over a broad range of pH spanning 58. Common modifiers of COM and its solute (oxalate) are polyprotic acids. Few studies report the effects of oxalate speciation on COM growth. Moreover, it remains to be determined how pH influences the efficacy of polyprotic molecules used to inhibit COM growth, such as citrate (CA) and its molecular analogue hydroxycitrate (HCA). Here, we show that there is a dramatic reduction in the rate of COM growth in the lower limit of physiological pH, commensurate with the loss of oxalate net negative charge. Our findings reveal that CA and HCA exhibit dual modes of action as promoters and inhibitors of COM crystallization at low and high pH, respectively. We also observe distinct differences in the efficacy of each modifier and discuss how local changes in pH near charged crystal interfaces can have a marked impact on local supersaturation and the speciation of adsorbed modifiers. On the basis of our observations of COM crystallization, it is reasonable to expect that changes in pH, or more specifically the speciation of solute and modifier(s), could similarly impact the growth (and growth inhibition) of other crystals employing polyprotic acids.
机译：多蛋白酸倾向于是合成，天然和生物系统中晶体的非常有效的改性剂。实例包括钙生物碳化钙，其中用羧酸装饰的蛋白质和有机酸充当晶体生长的抑制剂。对于涉及病理疾病的晶体，生长培养基的pH的大变化可以改变多蛋白酸的形态。对于由多栓塞组成的钙矿物质尤其如此，其中溶质物种的变化影响过饱和，因此晶体生长的动力学。在这里，我们探讨了溶质和改性剂形态的综合影响，选择草酸钙单水合物（COM）作为钙化的代表性系统。 COM是人肾结石的主要组成部分，其中体内结晶发生在跨越58的广泛的pH跨越58中。COM及其溶质（草酸盐）的常见改性剂是多胶酸。少数研究报告了草酸盐物质对COM生长的影响。此外，仍有待确定pH如何影响用于抑制COM生长的多种分子的功效，例如柠檬酸盐（CA）及其分子类似物羟基柠檬酸（HCA）。在这里，我们表明，在生理pH的下限下的COM增长率的速度显着降低，与草酸盐净负电荷的损失相称。我们的研究结果表明，Ca和HCa分别表现出作为促进剂和低pH结晶的启动子和抑制剂的双重作用方式。我们还观察到每种改性剂的功效的不同差异，并讨论如何对充电晶体界面附近的pH值的局部变化可以对局部过饱和和吸附改性剂的形态产生显着的影响。在我们对COM结晶的观察结果的基础上，期望pH值或更具体地描述溶质和改性剂的形态，可能类似地影响使用多蛋白酸的其他晶体的生长（和生长抑制）。

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  • 来源
    《Crystal growth & design》 |2017年第8期|共9页
  • 作者

    Chung Jihae; Sosa Ricardo; Rimer Jeffrey D.;

  • 作者单位

    Univ Houston Dept Chem &

    Biomol Engn Houston TX 77204 USA;

    Univ Houston Dept Chem &

    Biomol Engn Houston TX 77204 USA;

    Univ Houston Dept Chem &

    Biomol Engn Houston TX 77204 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 晶体学;
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