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首页> 外文期刊>Crystal growth & design >Synthesis and Crystal Structure of Solvated Complexes of Copper(II) with Serine and Phenanthroline and Their Solid-State-to-Solid-State Transformation into One Stable Solvate
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Synthesis and Crystal Structure of Solvated Complexes of Copper(II) with Serine and Phenanthroline and Their Solid-State-to-Solid-State Transformation into One Stable Solvate

机译：用丝氨酸和菲咯啉的铜（II）溶剂化合物的合成和晶体结构及其固态与固态转化成一个稳定的溶剂化物

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摘要

Reactions of copper(II) sulfate with 1,10-phenanthroline, L-serine, and a base were investigated under different solution-based and mechanochemical synthetic procedures. Six complexes with serine were obtained: [Cu(L-ser)(H2O)(phen)](2)SO4 center dot xH(2)O (x = 4, 6, or 10; 1 center dot 4H(2)O, 1 center dot 6H(2)O, and 1 center dot 10H(2)O), [Cu(L-ser)(H2O)(phen)][Cu(L-ser)(CH3OH)-(phen)]SO4 center dot 3H(2)O center dot CH3OH (1 center dot 2 center dot 3H(2)P-CH3OH), [Cu(L-ser)(CH3OH)(phen)](2)SO4. xCH(3)OH (x = 2 or 2.5; 2 center dot 2CH(3)OH and 2 center dot 2.5CH(3)OH), and two without serine: [Cu(SO4)(phen)(2)]center dot xH(2)O (x = 4.5 or 6.75; 3 center dot 4.5H(2)O and 3 center dot 6.75H(2)O) (phen = 1,10-phenanthroline, L-ser = L-serinato). The X-ray crystal structure analysis of serine-containing complexes revealed extensive hydrogen bonding and pi-interactions that link complex cations, sulfate anions, and solvent molecules into three-dimensional architectures. Most of the water/methanol solvent molecules in these porous compounds are found in channels, some in pockets connected to channels, be exchanged in vapors of the other solvent. Along with the solvent exchange, the solvent molecule apically coordinated to copper(II) is also exchanged in some transformations. By neat grinding, all serine-containing complexes transform into 1 center dot 6H(2)O. Quantum chemical calculations were done for compounds 1 center dot 4H(2)O and 1 center dot 6H(2)O in the gas phase and an aqueous (or methanol) surrounding. 1 center dot 6H(2)O and 3 center dot 4.5H(2)O showed pronounced antiproliferative activity toward human breast and lung tumor cell lines.
机译：在不同的溶液和机械化学合成程序下研究了铜（II）硫酸铜（II）硫酸盐，L-丝氨酸和碱。获得丝氨酸的六个络合物：[Cu（L- Ser）（H 2 O）（Ph）]（2）SO4中心点XH（2）O（X = 4,6或10; 1中心点4H（2）O. ，1中心点6h（2）o和1中心点10h（2）o），[Cu（l-ser）（H 2 O）（phO）] [Cu（L-Ser）（CH 3 OH） - （Phen）] SO4中心点3H（2）O中心点CH3OH（1中心点2中心点3H（2）P-CH 3 OH），[Cu（L- Ser）（CH 3 OH）（Phen）]（2）SO4。 XCH（3）OH（x = 2或2.5; 2中心点2ch（3）OH和2中心点2.5CH（3）OH），两种没有丝氨酸：[Cu（SO 4）（Phen）（2）]中心点XH（2）O（x = 4.5或6.75; 3中心点4.5h（2）o和3中心点6.75h（2）o）（phen = 1,10-菲利碱，L-ser = l-serinato） 。含丝氨酸配合物的X射线晶体结构分析揭示了将复合阳离子，硫酸根和溶剂分子连接到三维架构中的广泛的氢键和PI-相互作用。这些多孔化合物中的大多数水/甲醇溶剂分子在通道中发现，一些在连接到通道的袋中，在其他溶剂的蒸气中交换。随着溶剂交换，对铜（II）的溶剂分子也在一些转化中交换。通过整洁研磨，所有含丝氨酸的配合物转化为1中心点6h（2）o。在气相中的化合物1中心点4h（2）o和1中心点6h（2）o和周围的含水（或甲醇）进行量化的量子化学计算。 1中心点6h（2）o和3中心点4.5h（2）o显示出对人乳腺和肺肿瘤细胞系的明显抗增殖活动。

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  • 来源
    《Crystal growth & design》 |2017年第11期|共13页
  • 作者

    Vusak Darko; Prugovecki Biserka; Milic Dalibor; Markovic Marijana; Petkovic Ines; Kralj Marijeta; Matkovic-Calogovic Dubravka;

  • 作者单位

    Univ Zagreb Div Gen &

    Inorgan Chem Fac Sci Dept Chem Horvatovac 102a Zagreb 10000 Croatia;

    Univ Zagreb Div Gen &

    Inorgan Chem Fac Sci Dept Chem Horvatovac 102a Zagreb 10000 Croatia;

    Univ Zagreb Div Gen &

    Inorgan Chem Fac Sci Dept Chem Horvatovac 102a Zagreb 10000 Croatia;

    Inst Med Res &

    Occupat Hlth Ksaverska Cesta 2 POB 291 Zagreb 10001 Croatia;

    Univ Zagreb Div Gen &

    Inorgan Chem Fac Sci Dept Chem Horvatovac 102a Zagreb 10000 Croatia;

    Rudjer Boskovic Inst Div Mol Med Lab Expt Therapy Bijenicka 54 Zagreb 10000 Croatia;

    Univ Zagreb Div Gen &

    Inorgan Chem Fac Sci Dept Chem Horvatovac 102a Zagreb 10000 Croatia;

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  • 正文语种 eng
  • 中图分类 晶体学;
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