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首页> 外文期刊>Crystal growth & design >Relationships among Crystal Structures, Mechanical Properties, and Tableting Performance Probed Using Four Salts of Diphenhydramine
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Relationships among Crystal Structures, Mechanical Properties, and Tableting Performance Probed Using Four Salts of Diphenhydramine

机译：使用四种盐的二苯胺探测晶体结构，机械性能和压片性能之间的关系

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摘要

Clear understanding of the relationships among crystal structure, mechanical properties, and tableting performance is of enormous importance for successful development of tablet products. This study was aimed at systematically examining such relationships using four salts of diphenhydramine (DPH), a first-generation H-receptor antagonist, i.e., hydrochloride (DPH-HCl), citrate (DPH-Cit), saccharinate (DPH-Sac), and acesulfamate (DPH-Acs). The conformation and intermolecular interactions of DPH as well as crystal packing in the four salts were considerably different. Both the energy framework and visualization of the crystal structure revealed the greatest plasticity of DPH-Acs, which was characterized by drastically different intermolecular interactions in orthogonal directions. This was consistent with its facile bending behavior and the lowest hardness. The most plastic DPH-Acs also exhibited the best tabletability, which was accompanied by greater compressibility and compactibility as well as smaller elastic recovery than the other three salts. Among the three hard brittle DPH salts, higher crystal hardness corresponded to poorer tabletability. This work demonstrates the technological feasibility of understanding or even predicting tableting performance based on crystal structures and mechanical properties.
机译：清楚地了解晶体结构，机械性能和压片性能之间的关系，对平板产品的成功开发具有巨大的重要性。本研究旨在系统地使用四合一羟基胺（DPH），第一代H-受体拮抗剂，即盐酸盐（DPH-HCl），柠檬酸盐（DPH-CIT），糖酸盐（DPH-SAC）的四种盐来系统地检查这种关系。和乙酰磺酸盐（DPH-ACS）。 DPH的构象和分子间相互作用以及晶体填料在四个盐中相当不同。晶体结构的能量框架和可视化既显示了DPH-ACS的最大可塑性，其特征在于正交方向上的分子间相互作用。这与其容易弯曲行为和最低硬度一致。最多的塑料DPH-AC也表现出最佳的缩放性，伴随着更大的可压缩性和压缩性以及比其他三种盐的弹性恢复更小。在三种硬脆性DPH盐中，更高的晶体硬度对应于较差的缩放性。这项工作证明了理解的技术可行性，甚至基于晶体结构和机械性能预测压片性能。

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  • 来源
    《Crystal growth & design》 |2017年第11期|共11页
  • 作者

    Wang Chenguang; Paul Shubhajit; Wang Kunlin; Hu Shenye; Sun Changquan Calvin;

  • 作者单位

    Univ Minnesota Coll Pharm Dept Pharmaceut Pharmaceut Mat Sci &

    Engn Lab Minneapolis MN 55455 USA;

    Univ Minnesota Coll Pharm Dept Pharmaceut Pharmaceut Mat Sci &

    Engn Lab Minneapolis MN 55455 USA;

    Univ Minnesota Coll Pharm Dept Pharmaceut Pharmaceut Mat Sci &

    Engn Lab Minneapolis MN 55455 USA;

    Univ Minnesota Coll Pharm Dept Pharmaceut Pharmaceut Mat Sci &

    Engn Lab Minneapolis MN 55455 USA;

    Univ Minnesota Coll Pharm Dept Pharmaceut Pharmaceut Mat Sci &

    Engn Lab Minneapolis MN 55455 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 晶体学;
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