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首页> 外文期刊>Advances in Experimental Medicine and Biology >Chapter 12 Parasite-Associated Cancers (Blood Flukes/Liver Flukes)
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Chapter 12 Parasite-Associated Cancers (Blood Flukes/Liver Flukes)

机译：第12章寄生虫相关的癌症（血液氟虫/肝氟尿布）

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Abstract Parasitic infection remains as a persistent public health problem and can be carcinogenic. Three helminth parasites, namely, Clonorchis sinensis (liver fluke) and Opisthorchis viverrini as well as Schistosoma haematobium (blood fluke), are classified as Group 1 carcinogens by the World Health Organization's International Agency for Research on Cancer (IARC Infection with liver flukes {Opisthorchis viverrini, Opisthorchis felineus and Clonorchis sinensis),Woild Health Organization, International Agency for Research on Cancer, 2011). Infection by these parasites is frequently asymptomatic and is thus rarely diagnosed at early exposure. Persistent infection can cause severe cancer complications. Until now, the cellular and molecular mechanisms linking fluke infections to cancer formation have yet to be defined, although many studies have focused on these mechanisms in recent years, and numerous findings were made in various aspects of parasite-associated cancers. Herein, we only introduce the fluke-induced cholangiocarcinoma (CCA) and bladder carcinoma and mainly focus on key findings in the last 5 years.
机译：摘要寄生虫感染仍然是持续的公共卫生问题，可以是致癌性的。三个蠕虫寄生虫，即Clonorchis sinensis（肝氟克）和Opisthorchis Viverrini以及血吸虫血吸虫（血液荧光素）被归类为世界卫生组织癌症国际研究机构第1组致癌物（IARC感染肝氟普斯（Opisthorchis） Viverrini，Opisthorchis Felineus和Clonorchis Sinensis），Woild健康组织，国际癌症研究机构，2011）。这些寄生虫的感染通常是无症状的，因此在早期暴露时很少被诊断。持续感染可能导致严重的癌症并发症。到目前为止，尚未定义将Fluke感染与癌症形成联系起来的细胞和分子机制，尽管近年来许多研究重点是这些机制，并且在寄生虫相关癌症的各个方面进行了许多发现。在此，我们仅介绍氟克诱导的胆管癌（CCA）和膀胱癌，主要关注过去5年的关键结果。

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