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首页> 外文期刊>ACS applied materials & interfaces >Polypeptide-Based Theranostics with Tumor-Microenvironment-Activatable Cascade Reaction for Chemo-ferroptosis Combination Therapy
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Polypeptide-Based Theranostics with Tumor-Microenvironment-Activatable Cascade Reaction for Chemo-ferroptosis Combination Therapy

机译：基于多肽的Theranostics，具有肿瘤微环境可激活的级联反应，用于化学硬化组合治疗

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摘要

Nanoengineering of polymer-based therapeutic carriers is promising for precise cancer treatment. Herein, we report the fabrication of polypeptide vehicles encapsulated with anticancer drug of cisplatin (Pt drug) and Fe3O4 nanoparticles (denoted as Pt&Fe3O4@PP) as theranostics for T-2-weighted magnetic resonance imaging (MRI)-guided chemo-ferroptosis combination therapy. The number of Fe3O4 nanoparticles per polypeptide vehicle is well controlled by adjusting the added amount of Fe(3)O(4 )nanoparticles. The tumor microenvironment can trigger the release of Pt drug and Fe2/3+, which could induce the intracellular cascade reaction to generate sufficient center dot OH for ferroptosis therapy. Moreover, the released Pt drug can cause the apoptosis of tumor cells. Meanwhile, the encapsulated Fe3O4 nanoparticles can also be used for T-2-weighted MRI of tumor. Both in vitro and in vivo results indicate that the reported Pt&Fe3O4@PP can efficiently inhibit cancer cell growth without causing significant systemic toxicity. Importantly, polypeptide vehicles could significantly reduce the side effect of free Pt drug in vivo and therefore improve the drug delivery efficacy. Our findings suggest that polypeptide-based theranostics with tumor-microenvironment-activatable cascade reaction have great potential in biomedical applications.
机译：基于聚合物的治疗载体的纳米工程是有前途的精确癌症治疗。在此，我们报告用SISPLATIN（PT药物）和Fe3O4纳米颗粒的抗癌药物包封的多肽载体的制备作为T-2加权磁共振成像（MRI） - 帘化学 - 铁凋亡组合治疗的Theranostics 。通过调节加入的Fe（3）O（4）纳米颗粒，通过调节加入的Fe（3）O（4）纳米颗粒，得到每种多肽载体的Fe3O4纳米颗粒的数量。肿瘤微环境可以触发Pt药物和Fe2 / 3 +的释放，这可以诱导细胞内级联反应，以产生足够的中心点OH以进行脱裂疗法。此外，释放的PT药物会导致肿瘤细胞的凋亡。同时，包封的Fe3O4纳米颗粒也可用于肿瘤的T-2加权MRI。体外和体内结果表明，报告的PT＆Fe3O4 @ PP可以有效地抑制癌细胞生长而不会导致显着的全身毒性。重要的是，多肽载体可以显着降低体内游离Pt药物的副作用，从而提高药物递送功效。我们的研究结果表明，具有肿瘤微环境 - 可活化级联反应的多肽的Theranostics在生物医学应用中具有很大的潜力。

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  • 来源
    《ACS applied materials & interfaces》 |2020年第18期|共10页
  • 作者

    Gao Zhiliang; He Ting; Zhang Peiyu; Li Xiaoyu; Zhang Yinling; Lin Jing; Hao Jingcheng; Huang Peng; Cui Jiwei;

  • 作者单位

    Shandong Univ Key Lab Colloid &

    Inteiface Chem Sch Chem &

    Chem Engn Minist Educ Jinan 250100 Shandong Peoples R China;

    Shenzhen Univ Marshall Lab Biomed Engn Int Canc Ctr Lab Evolutionary Theranost LET Sch Biomed Engn Hl Shenzhen 518060 Peoples R China;

    Shandong Univ Key Lab Colloid &

    Inteiface Chem Sch Chem &

    Chem Engn Minist Educ Jinan 250100 Shandong Peoples R China;

    Shandong Univ Key Lab Colloid &

    Inteiface Chem Sch Chem &

    Chem Engn Minist Educ Jinan 250100 Shandong Peoples R China;

    Shenzhen Univ Marshall Lab Biomed Engn Int Canc Ctr Lab Evolutionary Theranost LET Sch Biomed Engn Hl Shenzhen 518060 Peoples R China;

    Shenzhen Univ Marshall Lab Biomed Engn Int Canc Ctr Lab Evolutionary Theranost LET Sch Biomed Engn Hl Shenzhen 518060 Peoples R China;

    Shandong Univ Key Lab Colloid &

    Inteiface Chem Sch Chem &

    Chem Engn Minist Educ Jinan 250100 Shandong Peoples R China;

    Shenzhen Univ Marshall Lab Biomed Engn Int Canc Ctr Lab Evolutionary Theranost LET Sch Biomed Engn Hl Shenzhen 518060 Peoples R China;

    Shandong Univ Key Lab Colloid &

    Inteiface Chem Sch Chem &

    Chem Engn Minist Educ Jinan 250100 Shandong Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    polypeptides; self-assembly; theranostics; drug delivery; cancer therapy;

    机译：多肽;自我组装;Theranostics;药物递送;癌症治疗;

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