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首页> 外文期刊>ACS applied materials & interfaces >Epitope Molecularly Imprinted Polymer Nanoparticles for Chemo-/Photodynamic Synergistic Cancer Therapy Guided by Targeted Fluorescence Imaging
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Epitope Molecularly Imprinted Polymer Nanoparticles for Chemo-/Photodynamic Synergistic Cancer Therapy Guided by Targeted Fluorescence Imaging

机译：表位分子印迹聚合物纳米粒子用于化学/光动力协同癌症治疗，由靶向荧光成像引导

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摘要

It is a still tough task to precisely target cancer cells and efficiently improve the therapeutic efficacy of various therapies at the same time. Here, dual-template imprinting polymer nanoparticles (MIPs) with a core-shell structure were prepared, in which fluorescent silica nanoparticles (FSiO2) were the core and the imprinted polymer layers were the outermost shell. The imprinted layer was designed and constructed via free-radical precipitation approach on the surface of FSiO2, which simultaneously encapsulated gadolinium-doped silicon quantum dots and photosensitizers (Ce6). During the polymerization process, two template molecules were introduced into the mixtures, one was the epitope of CDS9 protein (YNCPNP-TADCK), which was overexpressed on the surface of a great deal of the solid cancers, and the other was antitumor agent doxorubicin (DOX) to be used for chemotherapy. Furthermore, the embedded Ce6 could generate toxic O-1(2) under 655 nm laser irradiation to kill cancer cells, combining with the loaded-DOX to obtain a synergistic cancer therapy. Moreover, owing to the introduction of gadolinium-doped silicon quantum dots, Ce6, and DOX, the MIPs were endowed with targeted fluorescence imaging (FI) and MR imaging (MRI). In vitro and in vivo experiments had been conducted to demonstrate the excellent targeting ability and desirable treatment effect with negligible toxicity to healthy tissues and organs. As a consequence, the designed MIPs can promote the development of targeted recognition against biomarkers and precise treatment guided with cell imaging tools.
机译：精确靶向癌细胞并有效地同时改善各种疗法的治疗效果是一种艰巨的任务。这里，制备具有核 - 壳结构的双模板压印聚合物纳米颗粒（MIPS），其中荧光二氧化硅纳米颗粒（FSIO2）是核心，印迹聚合物层是最外壳。通过FSIO2的表面上通过自由基沉淀方法设计和构建压印层，其同时包封掺杂钆掺杂的硅量子点和光敏剂（CE6）。在聚合过程中，将两种模板分子引入混合物中，是CDS9蛋白（YNCPNP-TADCK）的表位，其在固体癌症的大量表面上过表达，而另一个是抗肿瘤剂DOXORUBICIN（ dox）用于化疗。此外，嵌入式CE6可以在655nm激光照射下产生毒性O-1（2）以杀死癌细胞，与负载-ODX组合以获得协同癌症治疗。此外，由于引入了钆掺杂的硅量子点，CE6和DOX，MIPS赋予靶向荧光成像（FI）和MR成像（MRI）。已经进行体外和体内实验，以证明对健康组织和器官的毒性可忽略的靶向能力和理想的治疗效果。因此，设计的MIPS可以促进针对生物标志物的有针对性识别的发展和用细胞成像工具引导的精确处理。

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