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首页> 外文期刊>ACS applied materials & interfaces >Cell Membrane-Specific Fluorescent Probe Featuring Dual and Aggregation-Induced Emissions
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Cell Membrane-Specific Fluorescent Probe Featuring Dual and Aggregation-Induced Emissions

机译：细胞膜特异性荧光探针，具有双重和聚集诱导的排放

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摘要

A cell membrane-specific fluorescent probe was prepared by conjugating a coumarin dye with a tetraphenylethene (TPE) derivative through an alpha,beta-unsaturated ketone connection. The probe has two absorptions: one from the TPE moiety at 300 nm and a second one due to the coumarin moiety at 458.5 nm. The probe fluoresces at 470 nm in tetrahydrofuran (THF) solution. The probe exhibits a useful aggregation-induced emission (AIE) property. A gradual increase in the water content of a THF solution causes a significant decrease and 12 nm red shift in the fluorescence peak at 470 nm, giving rise to a new strong fluorescence peak at 591 nm at a 95% water content. The probe is hydrophobic with an AIE property and binds to cell membranes, resulting in 591 nm fluorescence upon implantation into cells. The probe possesses a long retention time despite the lack of a long, cell membrane-anchored hydrophobic alkyl chain, which is typical for traditional membrane-specific probes. Our probe also displays low cytotoxicity and excellent photostability.
机译：通过通过α，β-不饱和酮连接将香豆素染料与四苯基乙烯（TPE）衍生物缀合来制备细胞膜特异性荧光探针。探针具有两种吸收：由于458.5nm的香豆素部分，来自TPE部分的两个吸收剂，并且第二次吸收剂。在四氢呋喃（THF）溶液中470nm处的探针荧光。探针表现出有用的聚集诱导的发射（AIE）性质。 THF溶液的水含量的逐渐增加导致470nm处的荧光峰值的显着降低和12nm的红色移位，在591nm处产生95％的水含量的新的强荧光峰。探针是疏水的，具有AIE性质并与细胞膜结合，导致植入细胞后591nm荧光。尽管缺乏长的细胞膜锚定的疏水烷基链，但探针具有长的保留时间，这对于传统膜特异性探针是典型的。我们的探针还显示出低细胞毒性和优异的光稳定性。

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