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首页> 外文期刊>ACS applied materials & interfaces >Printed Soft Optical Waveguides of PLA Copolymers for Guiding Light into Tissue
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Printed Soft Optical Waveguides of PLA Copolymers for Guiding Light into Tissue

机译：PLA共聚物的印刷软光波导，用于将光线引导到组织中

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摘要

The application of optical technologies in treating pathologies and monitoring disease states requires the development of soft, minimal invasive and implantable devices to deliver light to tissues inside the body. Here, we present soft and degradable optical waveguides from poly(D-L-lactide) and derived copolymers fabricated by extrusion printing in the desired dimensions and shapes. The obtained optical waveguides propagate VIS to NIR light in air and in tissue at penetration depths of tens of centimeters. Besides, the printed waveguides have elastomeric properties at body temperature and show softness and flexibility in the range relevant for implantable devices in soft organs. Printed waveguides were able to guide light across 8 cm tissue and activate photocleavage chemical reactions in a photoresponsive hydrogel (in vitro). The simplicity and flexibility of the fiber processing method and the optical and mechanical performance of the obtained waveguides exemplify how rational study of medically approved biomaterials can lead to useful inks for printing cost-effective and flexible optical components for potential use in medical contexts.
机译：光学技术在治疗病理学和监测疾病状态时需要开发软，最小的侵入性和可植入装置，以将光线传递到体内的组织。这里，我们用挤出印刷制造的聚（D-L-丙交酯）和通过挤出印刷的衍生共聚物呈现柔软和可降解的光波导。所获得的光波导在空气中传播到NIR光，在几十厘米的渗透深度处的组织中。此外，印刷波导在体温下具有弹性体性能，并在软器官中的可植入装置的范围内显示柔软性和柔韧性。印刷的波导能够引导横跨8厘米组织的光并激活光致荧光在光致胶凝水中（体外）中的光学发射化学反应。所获得的波导的光纤处理方法的简单性和灵活性和光学和机械性能的说明了医学上批准的生物材料的合理研究如何导致打印成本有效和柔性光学组件的有用油墨，以便在医学环境中使用。

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