Second Near-Infrared Aggregation-Induced Emission Fluorophores with Phenothiazine Derivatives as the Donor and 6,7-Diphenyl-[1,2,5]Thiadiazolo[3,4-g]Quinoxaline as the Acceptor for In Vivo Imaging

Li Shun; Yin Changfeng; Wang Ruonan; Fan Quli; Wu Wei; Jiang Xiqun

首页> 外文期刊>ACS applied materials & interfaces >Second Near-Infrared Aggregation-Induced Emission Fluorophores with Phenothiazine Derivatives as the Donor and 6,7-Diphenyl-[1,2,5]Thiadiazolo[3,4-g]Quinoxaline as the Acceptor for In Vivo Imaging

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Second Near-Infrared Aggregation-Induced Emission Fluorophores with Phenothiazine Derivatives as the Donor and 6,7-Diphenyl-[1,2,5]Thiadiazolo[3,4-g]Quinoxaline as the Acceptor for In Vivo Imaging

机译：第二近红外聚集诱导的发射荧光团，其具有吩噻嗪衍生物作为供体和6,7-二苯基 - [1,2,5]噻二唑[3,4 -g]喹喔啉作为体内成像的受体

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Traditional organic fluorophores generally have hydrophobic conjugated backbones and exhibit an aggregation-caused quenching emission property, which limits greatly their applications in the biological field. Aggregation-induced emission (ME) fluorophores can breakthrough this shortcoming and are more promising in biological imaging. In this paper, we synthesized three novel donor-acceptor-donor-type second near-infrared (NIR-II) fluorophores and studied their geometric and electronic structures and photophysical properties by both theoretical and experimental studies. All the three fluorophores had typical AIE characteristics, and their emission wavelength spanned the traditional near-infrared and NIR-II regions. They exhibited much stronger fluorescence after being encapsulated in polymer nanoparticles (NPs) than in solutions, and the fluorophore-loaded NPs had desirable biosafety and significant tumor accumulation, indicating that they have great application potentials in tumor detection.

机译：传统的有机荧光团通常具有疏水性共轭骨架，并且具有引起的引起的淬火发射性能，这极大地限制了它们在生物领域的应用。聚集诱导的发射（ME）荧光团可以突破这种缺点，并且在生物成像中更有前景。在本文中，我们合成了三种新型供体 - 供体型第二近红外（NIR-II）荧光团，并通过理论和实验研究研究了它们的几何和电子结构和光物理性质。所有三个荧光团都具有典型的AIE特性，并且它们的排放波长跨越传统的近红外和尼河II区。它们在将聚合物纳米颗粒（NPS）中封装之后呈现更强烈的荧光，并且荧光团的NPS具有理想的生物安全和显着的肿瘤积累，表明它们具有巨大的肿瘤检测潜力。

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《ACS applied materials & interfaces》 |2020年第18期|共6页
作者
Li Shun; Yin Changfeng; Wang Ruonan; Fan Quli; Wu Wei; Jiang Xiqun;
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作者单位

Nanjing Univ Coll Chem &

Chem Engn Dept Polymer Sci &

Engn Nanjing 210023 Peoples R China;

Nanjing Univ Coll Chem &

Chem Engn Dept Polymer Sci &

Engn Nanjing 210023 Peoples R China;

Nanjing Univ Coll Chem &

Chem Engn Dept Polymer Sci &

Engn Nanjing 210023 Peoples R China;

Nanjing Univ Posts &

Telecommun Key Lab Organ Elect &

Informat Displays Nanjing 210023 Peoples R China;

Nanjing Univ Coll Chem &

Chem Engn Dept Polymer Sci &

Engn Nanjing 210023 Peoples R China;

Nanjing Univ Coll Chem &

Chem Engn Dept Polymer Sci &

Engn Nanjing 210023 Peoples R China;

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正文语种 eng
中图分类化学工业;
关键词
second near-infrared fluorescent probes; aggregation-induced emission; polymer nanoparticles; tumor imaging;

机译：第二近红外荧光探针;聚集诱导的发射;聚合物纳米粒子;肿瘤成像;

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1. Second Near-Infrared Aggregation-Induced Emission Fluorophores with Phenothiazine Derivatives as the Donor and 6,7-Diphenyl-[1,2,5]Thiadiazolo[3,4-g]Quinoxaline as the Acceptor for In Vivo Imaging [J] . Li Shun, Yin Changfeng, Wang Ruonan, ACS applied materials & interfaces . 2020,第18期

机译：第二近红外聚集诱导的发射荧光团，其具有吩噻嗪衍生物作为供体和6,7-二苯基 - [1,2,5]噻二唑[3,4 -g]喹喔啉作为体内成像的受体
2. New donor-π-acceptor sensitizers containing 5H-[1,2,5]thiadiazolo [3,4-f]isoindole-5,7(6H)-dione and 6H-pyrrolo[3,4-g]quinoxaline-6,8(7H)-dione units [J] . Hairong Li, Teck Ming Koh, Anders Hagfeldt, Chemical Communications . 2013,第24期

机译：含有5H- [1,2,5]噻二唑[3,4-f]异吲哚-5,7（6H）-二酮和6H-吡咯并[3,4-g]喹喔啉-6的新型供体-π-受体敏化剂， 8（7H）-二酮单元
3. Saturable absorption and two-photon absorption of 1,2,5-thiadiazolo [3,4-g]quinoxaline based derivatives with near-infrared fluorescence [J] . Du Yabing, Lin Xiaodong, Jia Tingjian, Optics Communications: A Journal Devoted to the Rapid Publication of Short Contributions in the Field of Optics and Interaction of Light with Matter . 2015,第Null期

机译：1,2,5-噻二唑并[3,4-g]喹喔啉类衍生物的近红外荧光饱和吸收和双光子吸收
4. Far-Red/Near-Infrared Fluorescent Bioprobes Based on Biocompatible Nanoparticles with Aggregation-Induced Emission Characteristics for Bioimaging Applications [C] . Wei Qin, Dan Ding, Bin Liu, Organic field-effect transistors XII : Organic semiconductors in sensors and bioelectronics VI . 2013

机译：基于具有聚集诱导发射特性的生物相容性纳米粒子的远红外/近红外荧光生物探针，用于生物成像应用
5. Assembly of 1H-isoindole derivatives by selective carbon–nitrogen triple bond activation: access to aggregation-induced emission fluorophores for lipid droplet imaging [O] . Dandan He, Zeyan Zhuang, Xu Wang, 2019

机译：通过选择性碳-氮三键活化组装1H-异吲哚衍生物：获得聚集诱导的发射荧光团用于脂质滴成像
6. Imaging: Conjugated Polymer Amplified Far-Red/Near-Infrared Fluorescence from Nanoparticles with Aggregation-Induced Emission Characteristics for Targeted In Vivo Imaging (Adv. Healthcare Mater. 3/2013) [O] . Ding, Dan, Li, Kai, Qin, Wei, 2013

机译：成像：共轭聚合物放大的纳米粒子的远红外/近红外荧光，具有聚集诱导的发射特性，可用于有针对性的体内成像（Adv。Healthcare Mater。3/2013）

Second Near-Infrared Aggregation-Induced Emission Fluorophores with Phenothiazine Derivatives as the Donor and 6,7-Diphenyl-[1,2,5]Thiadiazolo[3,4-g]Quinoxaline as the Acceptor for In Vivo Imaging

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