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首页> 外文期刊>ACS applied materials & interfaces >Stable and Well-Organized Near-Infrared Platinum(II)-Acetylide-Based Metallacycles-Mediated Cancer Phototherapy
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Stable and Well-Organized Near-Infrared Platinum(II)-Acetylide-Based Metallacycles-Mediated Cancer Phototherapy

机译：稳定且有组织良好的近红外铂（II） - 基于乙酰基的金属族介导的癌症光疗法

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摘要

The development of metallacycles with high stability and intense near-infrared (NIR) absorption is important for biomedical applications. However, very few molecular design strategies have been developed on such metallacycles. Herein, we report a new series of stable and well-defined NIR-absorbing metallacycles (M1-M3) through the Pt-acetylide coordination with highly efficient photoconversion performance for cancer phototherapy. The metallacycles showed high stability and strong NIR absorption, and the absorption peaks were red shifted approximately 30 nm in comparison with their corresponding precursors. The introduction of Pt into metallacycles promotes significant photoconversions, including the singlet-to-triplet and nonradiative transitions. Moreover, the fabricated M3 nanoparticles (M3-NPs) showed favorable photoconversions into both thermal effect and singlet oxygen generation upon NIR irradiation, achieving tumor ablation. This novel design of Pt-acetylide metallacycles possesses not only complex topological architectures but also a valuable paradigm for precise cancer phototherapy, which is important for grafting stimuli-responsive functional groups into metallacycles for the development of high-performance biomedical supramolecular materials.
机译：具有高稳定性和强烈近红外线（NIR）吸收的金属间俘获对生物医学应用很重要。然而，在这种金属间梗上已经开发了很少的分子设计策略。在此，我们通过PT-乙酰乙酰基的配位报告了一种新的稳定和明确定义的NIR吸收金属间母标（M1-M3），其具有高效的癌症光疗法的高效光电性能。金属间俘获表现出高稳定性和强烈的NIR吸收，并且与其相应的前体相比，吸收峰被红色移位约30nm。 Pt进入金属间族的引入促进了显着的光电转移，包括单态到三联和非抗体过渡。此外，制造的M3纳米颗粒（M3-NPS）显示出良好的光电输电体在NIR辐射时显示出热效应和单次氧气产生，实现肿瘤消融。这种新颖的Pt-乙酰化金属族设计不仅具有复杂的拓扑结构，而且具有精确的癌症光疗法的有价值的范式，这对于将刺激响应性官能团嫁接成高性能生物医学超分子材料的促进型致敏官能团是重要的。

著录项

  • 来源
    《ACS applied materials & interfaces》 |2020年第18期|共11页
  • 作者

    Li Guo; Zhang Xiangxiang; Zhao Weili; Zhao Weiwei; Li Feiyang; Xiao Kang; Yu Qi; Liu Shujuan; Zhao Qiang;

  • 作者单位

    Nanjing Univ Posts &

    Telecommun NUPT Key Lab Organ Elect &

    Informat Displays Inst Adv Mat IAM Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun NUPT Key Lab Organ Elect &

    Informat Displays Inst Adv Mat IAM Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun NUPT Key Lab Organ Elect &

    Informat Displays Inst Adv Mat IAM Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun NUPT Key Lab Organ Elect &

    Informat Displays Inst Adv Mat IAM Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun NUPT Key Lab Organ Elect &

    Informat Displays Inst Adv Mat IAM Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun NUPT Key Lab Organ Elect &

    Informat Displays Inst Adv Mat IAM Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun NUPT Key Lab Organ Elect &

    Informat Displays Inst Adv Mat IAM Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun NUPT Key Lab Organ Elect &

    Informat Displays Inst Adv Mat IAM Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun NUPT Key Lab Organ Elect &

    Informat Displays Inst Adv Mat IAM Nanjing 210023 Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    metallacycles; NIR-absorbing; Pt-acetylide; photodynamic therapy; photothermal therapy;

    机译：金属间;Nir吸收;Pt-乙酰化物;光动力疗法;光热疗法;

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