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首页> 外文期刊>ACS applied materials & interfaces >Effect of the Buffer on the Buildup and Stability of Tannic Acid/Collagen Multilayer Films Applied as Antibacterial Coatings
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Effect of the Buffer on the Buildup and Stability of Tannic Acid/Collagen Multilayer Films Applied as Antibacterial Coatings

机译：缓冲液对单宁酸/胶原多层膜施加抗菌涂料的施加和稳定性的影响

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摘要

The deposition of polyelectrolyte multilayers, obtained by the layer-by-layer (LbL) method, is a well-established technology to design biocompatible and antibacterial coatings aimed at preventing implant-associated infections. Several types of LbL films have been reported to exhibit antiadhesive and/or antibacterial (contact-killing or release-killing) properties governed not only by the incorporated compounds but also by their buildup conditions or their postbuildup treatments. Tannic acid (TA), a natural polyphenol, is known to inhibit the growth of several bacterial strains. In this work, we developed TA/collagen (TA/COL) LbL films built in acetate or citrate buffers at pH 4. Surprisingly, the used buffer impacts not only the physicochemical but also the antibacterial properties of the films. When incubated in physiological conditions, both types of TA/COL films released almost the same amount of TA depending on the last layer and showed an antibacterial effect against Staphylococcus aureus only for citrate-built films. Because of their granular topography, TA/COL citrate films exhibited an efficient release-killing effect with no cytotoxicity toward human gingival fibroblasts. Emphasis is put on a comprehensive evaluation of the physicochemical parameters driving the buildup and the antibacterial property of citrate films. Specifically, complexation strengths between TA and COL are different in the presence of the two buffers affecting the LbL deposition. This work constitutes an important step toward the use of polyphenols as an antibacterial agent when incorporated in LbL films.
机译：通过层 - 逐层（LBL）方法获得的聚电解质多层沉积是一种良好的设计，用于设计旨在预防植入物相关的感染的生物相容性和抗菌涂层。据报道，几种类型的LBL薄膜表现出抗炎和/或抗菌（接触杀灭或剥离杀灭）性质，不仅由掺入的化合物而且通过它们的累积条件或其后营养处理来治理。已知单宁酸（TA），天然多酚，抑制几种细菌菌株的生长。在这项工作中，我们开发了在pH4的乙酸盐或柠檬酸盐缓冲液中形成的Ta /胶原（Ta / col）Lbl薄膜。令人惊讶的是，使用的缓冲液不仅冲击薄膜的抗菌性能。当在生理条件下孵育时，两种类型的TA / COL膜根据最后一层释放出几乎相同量的Ta，并且仅针对柠檬酸薄膜对葡萄球菌的抗菌作用。由于它们的粒状地形，Ta / Col柠檬酸薄膜表现出一种有效的释放杀灭作用，没有细胞毒性朝向人的牙龈细胞纤维细胞。重点是综合评价促进柠檬酸薄膜的累积和抗菌性的物理化学参数。具体地，在两个影响LBL沉积的两个缓冲器的存在下，Ta和Col之间的络合强度是不同的。当在LBL薄膜中掺入时，该作品构成了在使用时使用多酚作为抗菌剂的重要步骤。

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