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首页> 外文期刊>ACS applied materials & interfaces >Enhanced Plasmon-Induced Resonance Energy Transfer (PIRET)-Mediated Photothermal and Photodynamic Therapy Guided by Photoacoustic and Magnetic Resonance Imaging
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Enhanced Plasmon-Induced Resonance Energy Transfer (PIRET)-Mediated Photothermal and Photodynamic Therapy Guided by Photoacoustic and Magnetic Resonance Imaging

机译：增强的等离子体诱导的谐振能量转移（PiRet）介导的光热和光动力学治疗，由光声和磁共振成像引导

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Phototherapy, including photothermal and photodynamic therapy, has attracted extensive attention due to its noninvasive nature, low toxicity, and high anticancer efficiency. The charge-separation mechanism of plasmon-induced resonance energy transfer (PIRET) has been increasingly employed to design nanotheranotic agents. Herein, we developed a novel and smart PIRET-mediated nanoplatform for enhanced, imaging-guided phototherapy. Prussian blue (PB) was incorporated into a Au@Cu2O nanostructure, which was then assembled with poly(allylamine) (PAH)-modified black phosphorus quantum dots (Au@PB@Cu2O@BPQDs/PAH nanocomposites). The hybrid nanosystem exhibited great absorption in the near-infrared region, as well as the ability to self-supply O-2 by catalyzing hydrogen peroxide and convert O-2 into singlet oxygen (O-1(2)) under 650 nm laser light (0.5 W/cm(2)) irradiation. In vitro and in vivo assays showed that the generated heat and toxic O-1(2) from Au@PB@Cu2O@BPQDs/PAH nanocomposites could effectively kill the cancer cells and suppress tumor growth. Moreover, the unique properties of the PB-modified nanosystem allowed for synergistic therapy with the aid of T-1-weighed magnetic resonance imaging (T-1-weighted magnetic resonance imaging) and photoacoustic imaging. This study presented a suitable way to fabricate smart PIRET-based nanosystems with enhanced photothermal therapy/photodynamic therapy efficacy and dual-modality imaging functionality. The great biocompatibility and low toxicity ensured their high potential for use in cancer therapy.
机译：光疗，包括光热和光动力治疗，由于其非侵入性，低毒性和高抗癌效率而引起了广泛的关注。等离子体诱导的共振能量转移（PiRet）的电荷分离机制已经越来越多地用于设计纳米菌药。在此，我们开发了一种新颖且智能的纤维介导的纳米片，用于增强，显影引导的光疗法。将普鲁士蓝（PB）掺入Au @ Cu2O纳米结构中，然后用聚（烯丙胺）（PAH） - 涂覆的黑磷量子点（Au @ Pb @ Cu2O @ BPQDS / PAH纳米复合材料组装）组装。杂交纳米系统在近红外区域表现出极高的吸收，以及通过催化过氧化氢来自供应O-2的能力，并将O-2转化为单次氧气（O-1（2））下的650nm激光（0.5W / cm（2））辐照。体外和体内测定表明，来自Au @ Pb @ Cu2O @ BPQDS / PAH纳米复合材料的产生的热和毒性O-1（2）可以有效地杀死癌细胞并抑制肿瘤生长。此外，借助于T-1称重的磁共振成像（T-1加权磁共振成像）和光声成像，允许PB改性纳米系统的独特性能。本研究提出了一种合适的方法来制造基于智能皮级的纳米系统，具有增强的光热疗/光动力治疗疗效和双模成像功能。巨大的生物相容性和低毒性确保了它们在癌症治疗中使用的高潜力。

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